discontinued

AP11555PU-N DKK3 (C-term) antibody

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0.1 mg / €335.00

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Rabbit anti Human DKK3

AP11555PU-N

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  • AP11555PU-N

Product Description for DKK3

Rabbit anti Human DKK3.
Properties: (C-term)
Presentation: Purified
Product is tested for Paraffin Sections.

Properties for DKK3

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Purified
Reactivity Hu
Applications P
Clonality Polyclonal
Host Rabbit
Isotype Ig
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human DKK3.
Property C-term
Add. information Molecular weight: 38291 Da
Application ELISA 1:1,000.
Immunohistochemistry 1:50 - 1:100.
Background DKK3, like DKK1, DKK2, and DKK4, possesses an N-terminal signal peptide and 2 conserved cysteine-rich domains, which are separated by a linker region and contain 10 cysteine residues each. The second cysteine region has a putative lipid-binding function that may facilitate WNT/DKK interactions at the plasma membrane. The linker region contains 50 to 55 amino acids in DKK1, DKK2, and DKK4, whereas in DKK3 it contains only 12 amino acids. All DKKs have several potential sites for cleavage by furin-type proteases. Northern blot analysis revealed wide expression of the DKK3 transcript, with highest expression in heart, brain, and spinal cord. In situ hybridization reveals highest expression in mouse brain, eye, and heart.
Concentration 0.25 mg/ml
General Readings
  1. Clark, H.F., et al., Genome Res. 13(10):2265-2270 (2003).
  2. Tsuji, T., et al., Biochem. Biophys. Res. Commun. 268(1):20-24 (2000).
  3. Krupnik, V.E., et al., Gene 238(2):301-313 (1999).
  4. Kobayashi, K., et al., Gene 282 (1-2), 151-158 (2002).
Storage Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Buffer System:
PBS with 0.09% (W/V) sodium azide
State:
Liquid Ig fraction
Purified
Specificity
Specificity:
This antibody detects DKK3 at C-term.
Species:
Human.

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