NB110-96878 DNA/RNA Damage antibody

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0.1 mg / €430.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Mouse anti DNA/RNA Damage 15A3

Product Description for DNA/RNA Damage

Mouse anti DNA/RNA Damage 15A3.
Presentation: Purified
Product is tested for Immunoprecipitation, Enzyme Immunoassay, Immunocytochemistry/Immunofluorescence, Paraffin Sections.

Properties for DNA/RNA Damage

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms 8-hydroxy-2'-deoxyguanosine, 8-hydroxyguanine and 8-hydroxyguanosine
Presentation Purified
Applications E, ICC/IF, IP, P
Clonality Monoclonal
Clone 15A3
Host Mouse
Isotype IgG2b
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
8-hydroxy-guanosine-BSA and
Isotype control AM03110PU-N, SM12P
Application ELISA, ELISA and IH May also be used on immunoaffinity columns. See procedure guide for specific information., ELISA
Background DNA or RNA damage is due to environmental factors and normal metabolic processes inside the cell, that then hinder the ability of the cell to carry out its functions. There are four main types of DNA due to endogenous cellular processes and they are oxidation, alkylation, hydrolysis and mismatch of the bases. During the oxidation of bases, highly reactive chemical entities collectively known as RONS, occurs. RONS stands for reactive oxygen and nitrogen species and includes nitric oxide, superoxide, hydroxyl radical, hydrogen peroxide and peroxynitrite. Numerous studies have shown that RONS causes a variety of issues including DNA damage (1). 8-hydroxyguanine, 8-hydroxy-2'-deoxyguanonsine and 8-hydroxyguanosine are all RNA and DNA markers of oxidative damage. 8-hydroxy-2'-guanosine is produced by reactive oxygen and nitrogen species including hydroxyl radical and peroxynitrite. Specifically its high biological relevance is due to its ability to induce G to T transversions, which is one of the most frequent somatic mutations (2). 8-hydroxy-guanine has been the most frequently studied type of DNA base damage, with studies in diabetes, and cancer. Base modifications of this type arise from radical-induced hydroxylation and cleavage reactions of the purine ring (3, 4). And finally, 8-hydroxy-guanosine, like 8-hydroxy-2'-guanosine, induces a mutagenic transversion of G to T in DNA. Its role has specifically been tested in the development of diabetes, hypertension and strokes (5, 6, and 7).
Concentration 0.65 mg/ml
Storage Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Format
Purification:
protein G purified
Buffer System:
0.1% Sodium Azide
Purity:
protein G purified
State:
Purified
Specificity
Specificity:
Recognizes markers of oxidative damage to DNA (8-hydroxy-2

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