AM03176SU-N DOG1 antibody

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Rabbit anti Human DOG1 BV10

Product Description for DOG1

Rabbit anti Human DOG1 BV10.
Presentation: Supernatant
Product is tested for Paraffin Sections.

Properties for DOG1

Product Category Primary Antibodies
Quantity 0.5 ml
Synonyms DOG-1, PKC theta, Protein Kinase C theta
Presentation Supernatant
Reactivity Hu
Applications P
Clonality Monoclonal
Clone BV10
Host Rabbit
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Synthetic peptide from the C-Terminus of Human DOG1 protein
Application Immunohistochemcitry on Paraffin Sections: Use DOG1 antibody at 1/25-1/50 dilution in an ABC method with an incubation period of 30-60 minutes at room temperature. Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining.
Positive Control: Gastrointestinal tissue.
Background DOG1 (Protein kinase C theta), the novel marker, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of kit or PDGFR alpha mutation status. Reactivity for DOG1 may aid in the diagnosis of GISTs, including PDGFRA mutants that fail to express KIT antigen, and lead to appropriate treatment with imatinib mesylate, an inhibitor of the KIT tyrosine kinase.
Storage Store the antibody undiluted at 2-8°C.
Shelf life: one year from despatch.
Buffer System:
Buffer pH 7.5, containing BSA as stabilizer and Sodium Azide as a preservative.
Liquid Tissue Culture Supernatant
This antibody detects DOG1.
Cellular Localization:Cytoplasmic and membrane.

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