AP20861PU-N DOK2 / p56 dok2 pTyr299 antibody

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0.1 mg / €350.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Rabbit anti Human, Mouse DOK2 / p56 dok2

Product Description for DOK2 / p56 dok2

Rabbit anti Human, Mouse DOK2 / p56 dok2.
Properties: pTyr299
Presentation: Aff - Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot.

Properties for DOK2 / p56 dok2

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms Docking protein 2, Downstream of tyrosine kinase 2, p56(dok-2), p56Dok-2
Presentation Aff - Purified
Reactivity Hu, Ms
Applications ICC/IF, WB
Clonality Polyclonal
Host Rabbit
Molecular weight ~ 56 kDa
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
O60496
Immunogen:
Synthetic phosphopeptide derived from human Dok-2 around the phosphorylation site of Tyrosine 299.
GeneID:
9046
Property pTyr299
Application Western blot: 1/500 - 1/1000.
Immunofluorescence: 1/50 - 1/200.
Background Dok-1 associates with the Ras GTPase activating protein (Ras GAP) upon tyrosine phosphorylation. Evidence suggests that p62 Dok-1 is a substrate of the constitutive tyrosine kinase activity of p210 Bcr-Abl, a fusion protein caused by the t(9;22) translocation and associated with chronic myelogenous leukemia. Dok-1, as well as the tyrosine kinase substrates IRS-1 and Cas, is a member of a class of “docking” proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok-1 is suspected to be the substrate phosphorylated in response to stimulation by a number of growth factors, including PDGF, VEGF, Insulin and IGF. Dok-2 (also designated p56 Dok) has also been identified as a potential mediator of the effects of p210 Bcr-Abl.
Concentration 1.0 mg/ml
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Affinity chromatography (> 95% (by SDS-PAGE)
Buffer System:
Phosphate buffered saline (PBS), pH 7.2.
Preservatives:
0.05% sodium azide
State:
Liquid purified Ig fraction
Aff - Purified
Species Reactivity
Species reactivity (tested):
Human, Mouse.
Specificity
Specificity:
This antibody detects endogenous levels of Dok-2 protein when phosphorylated at Tyr299.
Gene ID 9046

Accessory Products

Proteins and/or Positive Controls

Proteins for DOK2 / p56 dok2 (3 products)

Catalog No. Species Pres. Purity   Source  

DOK2 / p56 dok2

DOK2 / p56 dok2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €438.00
  OriGene Technologies, Inc.

DOK2 / p56 dok2

DOK2 / p56 dok2 Human in vitro transl.
  Abnova Taiwan Corp.

DOK2 / p56 dok2

DOK2 / p56 dok2 Human
  Abnova Taiwan Corp.

Positive controls for DOK2 / p56 dok2 (2 products)

Catalog No. Species Pres. Purity   Source  

DOK2 Lysate

Western Blot: DOK2 Lysate [NBL1-09978] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for DOK2
  Novus Biologicals Inc.

DOK2 overexpression lysate

DOK2 overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.
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