NB120-3188 DR 3 antibody

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Mouse anti Human DR 3 B65


Product Description for DR 3

Mouse anti Human DR 3 B65.
Presentation: Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Flow Cytometry.

Properties for DR 3

Product Category Primary Antibodies
Quantity 0.5 ml
Presentation Purified
Reactivity Hu
Applications F, ICC/IF
Clonality Monoclonal
Clone B65
Host Mouse
Isotype IgG2a
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Recombinant full length protein (Human).
Isotype control AM03096PU-N
Background DR3 (also known as Apo3, WSL-1, TRAMP, and LARD) is expressed on lymphocytes. DR3 is one of death domain containing receptors and shows close sequence similarity to TNF receptor I. Upon overexpression, DR3 triggers responses that resemble those of TNFRI, mainly, NF-kB activation and apoptosis. The ligand for DR3 has been identified as Apo3L.
General Readings General / background references:Marsters SA et al. Identification of a ligand for the death-domain-containing receptor Apo3. Curr Biol 8:525-8 (1998). PubMed PMID: 9560343
Ashkenazi A & Dixit VM Death receptors: signaling and modulation. Science 281:1305-8 (1998). PubMed PMID: 9721089
Screaton GR et al. LARD: a new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing. Proc Natl Acad Sci U S A 94:4615-9 (1997). PubMed PMID: 9114039
Chinnaiyan AM et al. Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. Science 274:990-2 (1996). PubMed PMID: 8875942
Kitson J et al. A death-domain-containing receptor that mediates apoptosis. Nature 384:372-5 (1996). PubMed PMID: 8934525
Protein A purified
Buffer System:
10mM PBS, pH7.4, 0.2%BSA, 0.09% sodium azide
Protein A purified
Cross-reacts with Human.Not yet tested in other species.

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