discontinued

SP6256P DR6 (42-56) antibody

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50 µg / €210.00

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Rabbit anti Human DR6 (42-56)

SP6256P

Product Description for DR6 (42-56)

Rabbit anti Human DR6 (42-56).
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for DR6 (42-56)

Product Category Primary Antibodies
Quantity 50 µg
Presentation Aff - Purified
Reactivity Hu
Applications WB
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer AnaSpec

Datasheet Extract

Immunogen
Immunogen:
Rabbit anti-DR6 (NT) polyclonal antibody was raised against a peptide corresponding to amino acids 42 to 56 of human DR6 precursor (1). Peptide available as SP6256CP.
Application Western blot: 1/500 - 1:2000. HeLa and K562 whole cell lysate can be used as positive control and an approximately 68 kDa band can be detected. Other applications not tested. Optimal dilutions of this antibody are dependent on conditions and should be determined by the user.
Concentration 0.5 mg/ml
General Readings
  1. Pan G, Bauer JH, Haridas V, Wang S, Liu D, Yu G, et al. Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. FEBS Lett. 1998 Jul 24;431(3):351-6. PubMed PMID: 9714541.
Storage Store at +4oC or at -20oC if preferred. This product should be stored undiluted. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Format
State:
Aff - Purified
Specificity
Specificity:
This antibody recognises the death domain containing receptor DR6. DR6 is widely expressed in human tissues and cell lines. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6 (1). Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-?B and JNK. DR6 is widely expressed in human tissues and cell lines (1). The ligand for DR6 has not been identified.

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