AP31632SU-N DsbA-L antibody

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0.1 ml / €330.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Rabbit anti Human, Mouse DsbA-L

Product Description for DsbA-L

Rabbit anti Human, Mouse DsbA-L.
Presentation: Serum
Product is tested for Frozen Sections, Western blot / Immunoblot.

Properties for DsbA-L

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms Disulfide-bond-A oxidoreductase-like protein
Presentation Serum
Reactivity Hu, Ms
Applications C, WB
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Full length recombinant Mouse DsbA-L protein.
Application Western Blot: 1/1000.
Immunohistochemistry: 1/200.
Background Disulfide-bond-A oxidoreductase-like protein (DsbA-L, previously named as GST Kappa) is an adiponectin-interacting protein. DsbA-L is highly expressed in adipose tissue, and its expression level is negatively correlated with obesity in mice and humans. DsbA-L expression in 3T3-L1 adipocytes is stimulated by the insulin sensitizer
rosiglitazone and inhibited by the inflammatory cytokine TNFalpha. Polymorphism of DsbA-L gene has recently been implicated in insulin secretion and body fat distribution (Gao F et al., 2009). Overexpression of DsbA-L promotes adiponectin multimerization while suppressing DsbA-L expression by RNAi markedly and selectively reduces adiponectin levels and secretion in 3T3-L1 adipocytes. Recent studies identify DsbA-L as a key regulator for adiponectin biosynthesis (Liu et al., 2008).
Product Citations
Originator or purchased from resellers:
  1. Wang A, Liu M, Liu X, Dong LQ, Glickman RD, Slaga TJ, et al. Up-regulation of adiponectin by resveratrol: the essential roles of the Akt/FOXO1 and AMP-activated protein kinase signaling pathways and DsbA-L. J Biol Chem. 2011 Jan 7;286(1):60-6. doi: 10.1074/jbc.M110.188144. Epub 2010 Oct 27. PubMed PMID: 20980258. (Free PMC Article available, 5 images available)
General Readings
  1. Gao F, Fang Q, Zhang R, Lu J, Lu H, Wang C, et al. Polymorphism of DsbA-L gene associates with insulin secretion and body fat distribution in Chinese population. Endocr J. 2009;56(3):487-94. Epub 2009 Feb 19. PubMed PMID: 19225211.
  2. Liu M, Zhou L, Xu A, Lam KS, Wetzel MD, Xiang R, et al. A disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18302-7. doi: 10.1073/pnas.0806341105. Epub 2008 Nov 14. PubMed PMID: 19011089. (Free PMC Article available, 6 images available)
Storage Store the antibody undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Liquid Serum in 40% Glycerol.
Species Reactivity
Species reactivity (tested):
Human and Mouse.
Specific for the ~25 kDa DsbA-L protein in Western blots of 3T3-L1 adipocytes and Mouse white and brown adipose tissue lysate samples. It is suggested that you add 1% BSA to the antibody dilution buffer.

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