discontinued

NB110-81552 Dual specificity protein phosphatase 3 antibody

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0.05 mg / €440.00

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Chicken anti Canine, Human, Mouse, Rat Dual specificity protein phosphatase 3

Product Description for Dual specificity protein phosphatase 3

Chicken anti Canine, Human, Mouse, Rat Dual specificity protein phosphatase 3.
Product is tested for Western blot / Immunoblot.

Properties for Dual specificity protein phosphatase 3

Product Category Primary Antibodies
Quantity 0.05 mg
Reactivity Can, Hu, Ms, Rt
Applications WB
Clonality Polyclonal
Host Chicken
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
A2F3X2
Immunogen:
1-185
GeneID:
4758208
Application Western Blot, Western blotting, tissue or cell immunostaining. Recommended starting dilution for Western blot analysis is 1:500, for tissue or cell staining is 1:200. Optimal working dilutions must be determined by the end user, Western Blot
Background The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This protein maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.
Concentration 1 mg/ml
General Readings Hoyt,R., Zhu,W., Cerignoli,F., Alonso,A., Mustelin,T. and David,M. Cutting edge: selective tyrosine dephosphorylation of interferon-activated nuclear STAT5 by the VHR phosphatase. J. Immunol. 179 (6), 3402-3406 (2007)
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Format
Buffer System:
0.02% Sodium Azide
Specificity
Specificity:
DUSP3
Species:
Canine, Human, Mouse, Rat
Gene ID 4758208

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