bs-11546R DUSP6 antibody

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Rabbit anti Human, Mouse, Rat DUSP6

Product Description for DUSP6

Rabbit anti Human, Mouse, Rat DUSP6.
Presentation: Purified
Product is tested for Paraffin Sections, Western blot / Immunoblot.

Properties for DUSP6

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms Dual specificity protein phosphatase 6, MKP3, PYST1
Presentation Purified
Reactivity Hu, Ms, Rt
Applications P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer Bioss, Inc.

Datasheet Extract

KLH conjugated synthetic peptide derived from human DUSP6.
Background Mitogen-activated protein (MAP) kinases are a large class of proteins involved in signal transduction pathways that are activated by a range of stimuli and mediate a number of physiological and pathological changes in the cell. Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK/ERK, SAPK/JNK and p38. The members of the dual-specificity phosphatase protein family include MKP-1/CL100 (3CH134), VHR, PAC1, MKP-2, hVH-3 (B23), hVH-5, MKP-3, MKP-X, and MKP-4. Human MKP-3 maps to chromosome 12q22-q23 and encodes a 381 amino acid protein that specifically inactivates members of the ERK family and is expressed in a variety of tissues with the highest levels in heart and pancreas.
Product Citations
Originator or purchased from resellers:
  1. Li, Guang Y., et al. "HCV induced reduction in miR‐181a impairs CD4+ T cell responses via over‐expression of DUSP6." Hepatology (2014).
Storage Store at -20°C for 12 months.
Purified by Protein A and peptide affinity chromatography.
Buffer System:
Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.

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