discontinued

NB120-6305 Dynein antibody

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0.1 ml / €400.00

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Mouse anti Human Dynein 440,4

NB120-6305

Product Description for Dynein

Mouse anti Human Dynein 440,4.
Presentation: Ascites
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.

Properties for Dynein

Product Category Primary Antibodies
Quantity 0.1 ml
Presentation Ascites
Reactivity Hu
Applications E, WB
Clonality Monoclonal
Clone 440,4
Host Mouse
Isotype IgG2a
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
Cytoplasmic full length native protein (purified from chick brain) (Chicken).
Background Eukaryotic cells rely on actin and microtubule-based protein "motors" to generate intracellular movements. These protein "motors" contain specialized domains that hydrolyse ATP to produce force and movement along a cytoskeletal polymer (actin in the case of myosin family and microtubules in the case of the kinesin family and dyneins).Dynein has been implicated in cytoplasmic motile funtions, including chromosomal movement, retrograde organelle and axonal transport, the endocytic pathway, and the organization of the Golgi apparatus.In all cell types, dynein has the same basic structures and is composed of two or three distinct heavy chains (~450 kD), three intermediate chains (70-125 kD), and at least four light chains (15-25 kD) (Vallee RB & Shpetner.).
General Readings This product has been used in:Wordeman L et al. Chemical subdomains within the kinetochore domain of isolated CHO mitotic chromosomes. J Cell Biol 114:285-94 (1991). PubMed PMID: 1830054
Steuer ER et al. Localization of cytoplasmic dynein to mitotic spindles and kinetochores. Nature 345:266-8 (1990). PubMed PMID: 2139718
General / background references:Mocz G et al. Proteolytic analysis of domain structure in the beta heavy chain of dynein from sea urchin sperm flagella. Biochemistry 30:7225-31 (1991). PubMed PMID: 1830219
Vallee RB & Shpetner HS Motor proteins of cytoplasmic microtubules. Annu Rev Biochem 59:909-32 (1990). PubMed PMID: 2142876
Format
Purification:
Ascites
Purity:
Ascites
State:
Ascites
Specificity
Species:
Cross-reacts with Chicken and Human (kinetochores in isolated HeLa chromosomes. Does not cross-react with Hamster (CHO cell chromosomal dynein) or with dynein from Chlamydomonas flagella. Not yet tested in other species

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