AP05079PU-N DYRK antibody

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0.1 mg / €360.00
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Quick Overview

Sheep anti Human, Mouse, Rat DYRK

Product Description for DYRK

Sheep anti Human, Mouse, Rat DYRK.
Presentation: Purified
Product is tested for Immunoprecipitation, Western blot / Immunoblot.

Properties for DYRK

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms DYRK1A, Dual specificity YAK1-related kinase, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, MNB, MNBH
Presentation Purified
Reactivity Hu, Ms, Rt
Applications IP, WB
Clonality Polyclonal
Host Sheep
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Recombinant protein corresponding to amino acids 486 to 763 of the Mouse Dyrk1A protein.
Application Western Blot: 1 µg/ml.
Immunoprecipitation.
Immunofluoresecence: 1-10 µg/ml.
Background Dyrk, the vertebrate of Drosophilia minibrain, is a dual-specificity kinase predominately expressed in the central nervous system. The human clone has been isolated from the Downs' syndrome critical region and it is potentially implicated in the neuropathology of the disease. Main features of the protein include an N-terminal nuclear translocation signal, a putative leucine zipper domain, a core kinase domain with some similarity to kinases involved in cell cycle regulation and a C-terminal PEST sequence. The Dyrk kinase can be phosphorylated on tyrosine residues, leading to an active kinase that can phosphorylated itself or exogenous substrates on both tyrosine and serine/threonine residues. Dyrk can also multimerize and translocate to the nucleus. Present studies on Dyrk suggest a potential role for this kinase in the exit from the cell cycle and the beginning of neuronal differentiation.
Concentration 1.0 mg/ml
General Readings
  1. Kentrup H, Becker W, Heukelbach J, Wilmes A, Schürmann A, Huppertz C, et al. Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII. J Biol Chem. 1996 Feb 16;271(7):3488-95. PubMed PMID: 8631952.
  2. Song WJ, Sternberg LR, Kasten-Sportès C, Keuren ML, Chung SH, Slack AC, et al. Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome "critical region". Genomics. 1996 Dec 15;38(3):331-9. PubMed PMID: 8975710.
  3. Becker W, Joost HG. Structural and functional characteristics of Dyrk, a novel subfamily of protein kinases with dual specificity. Prog Nucleic Acid Res Mol Biol. 1999;62:1-17. PubMed PMID: 9932450.
Storage Store the antibody at -20°C.
Avoid repeated freezing and thawing.
Shelf life: One year from despatch.
Format
Buffer System:
Phosphate buffered saline with 0.08% Sodium Azide as preservative.
Purity:
Purified
State:
Liquid purified Ig (0.2 µm sterile filtered)
Purified
Specificity
Specificity:
This antibody recognizes DYRK.
Species:
Human, Mouse and Rat.

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