TA319637 DYRK1A (C-term) antibody

Rabbit Polyclonal DYRK1A Antibody

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0.1 mg / €325.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Rabbit anti Human, Mouse, Rat DYRK1A

TA319637

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  • TA319637

Product Description for DYRK1A

Rabbit anti Human, Mouse, Rat DYRK1A.
Properties: (C-term)
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.

Properties for DYRK1A

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms DYRK, Dual specificity YAK1-related kinase, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, HP86, MNB, MNBH, Protein kinase minibrain homolog
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications E, WB
Clonality Polyclonal
Host Rabbit
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q13627
Immunogen:
17 amino acid peptide near the carboxy terminus of human DYRK1A
GeneID:
1859
Property C-term
Application ELISA.
Western blot: 1-2 µg/ml.
Positive control: HeLa Cell Lysate.
Background DYRK1A is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family and is thought to be involved in neuronal differentiation, neurodegenerative diseases, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. DYRK1A phosphorylates several transcription factors such as p53, leading to inhibition of embryonic neuronal cell proliferation. DYRK1A associates with multiple proteins, including SPRED1 and SPRED2; this association appears to inhibit the phosphorylation activity of DYRK1A. Recent evidence also suggests that DYRK1A may be involved in the replication of HIV-1.
General Readings
  1. Park J, Oh Y, Chung KC. Two key genes closely implicated with the neuropathological characteristics in Down syndrome: DYRK1A and RCAN1. BMB Rep. 2009 Jan 31;42(1):6-15. PubMed PMID: 19192387.
  2. Park J, Oh Y, Yoo L, Jung MS, Song WJ, Lee SH, et al. Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells. J Biol Chem. 2010 Oct 8;285(41):31895-906. doi: 10.1074/jbc.M110.147520. Epub 2010 Aug 9. PubMed PMID: 20696760. (Free PMC Article available, 7 images available)
  3. Li D, Jackson RA, Yusoff P, Guy GR. Direct association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactions. J Biol Chem. 2010 Nov 12;285(46):35374-85. doi: 10.1074/jbc.M110.148445. Epub 2010 Aug 24. PubMed PMID: 20736167. (Free PMC Article available, 8 images available)
Storage Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Affinity chromatography purified via peptide column
Buffer System:
PBS containing 0.02% sodium azide
State:
Liquid Ig fraction
Aff - Purified
Species Reactivity
Species reactivity (tested):
Human, mouse, rat
Specificity
Specificity:
This antibody detects DYRK1A at C-term.
Multiple isoforms of DYRK1A are known to exist. DYRK1A antibody will not cross-react with other DYRK family members.

Accessory Products

Proteins and/or Positive Controls

Proteins for DYRK1A (6 products)

Catalog No. Species Pres. Purity   Source  

DYRK1A (full length, C-term DDK tag, transcript variant 1)

DYRK1A Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
SF9 cells
20 µg / €399.00
  OriGene Technologies, Inc.

DYRK1A

DYRK1A Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

DYRK1A

DYRK1A Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

DYRK1A

DYRK1A Human
  Abnova Taiwan Corp.

DYRK1A

DYRK1A Human
  Abnova Taiwan Corp.

DYRK1A

DYRK1A Human
  Abnova Taiwan Corp.

Positive controls for DYRK1A (1 products)

Catalog No. Species Pres. Purity   Source  

DYRK1A overexpression lysate

DYRK1A overexpression lysate
0.1 mg / €480.00
  OriGene Technologies, Inc.
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