TA319749 DYRK2 (C-term) antibody

Rabbit Polyclonal DYRK2 Antibody

See related secondary antibodies

Search for all "DYRK2"

0.1 mg / €371.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

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Rabbit anti Human DYRK2

TA319749

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Product Description for DYRK2

Rabbit anti Human DYRK2.
Properties: (C-term)
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.

Properties for DYRK2

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms Dual specificity tyrosine-phosphorylation-regulated kinase 2
Presentation Aff - Purified
Reactivity Hu
Applications E, WB
Clonality Polyclonal
Host Rabbit
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q92630
Immunogen:
18 amino acid peptide near the carboxy terminus of human DYRK2
GeneID:
8445
Property C-term
Application ELISA.
Western blot: 1-2 µg/ml.
Positive control: 293 Cell Lysate.
Background DYRK2 is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family that is thought to be involved in cellular proliferation and apoptosis. Under normal conditions, nuclear but not cytoplasmic DYRK2 is ubiquitinated by MDM2, leading to its constitutive degradation. However, upon exposure to genotoxic stress, ATM phosphorylates DYRK2, leading to its dissociation from MDM2 and its phosphorylation of p53, thereby inducing apoptosis. Recent evidence also suggests that DYRK2 may serve as a scaffold that facilitates assembly of an E3 ubiquitin ligase.
General Readings
  1. Becker W, Weber Y, Wetzel K, Eirmbter K, Tejedor FJ, Joost HG. Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. J Biol Chem. 1998 Oct 2;273(40):25893-902. PubMed PMID: 9748265.
  2. Yoshida K. Role for DYRK family kinases on regulation of apoptosis. Biochem Pharmacol. 2008 Dec 1;76(11):1389-94. doi: 10.1016/j.bcp.2008.05.021. Epub 2008 Jul 2. PubMed PMID: 18599021.
  3. Taira N, Yamamoto H, Yamaguchi T, Miki Y, Yoshida K. ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage. J Biol Chem. 2010 Feb 12;285(7):4909-19. doi: 10.1074/jbc.M109.042341. Epub 2009 Dec 4. PubMed PMID: 19965871. (Free PMC Article available, 8 images available)
Storage Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Affinity chromatography purified via peptide column
Buffer System:
PBS containing 0.02% sodium azide
State:
Liquid Ig fraction
Aff - Purified
Species Reactivity
Species reactivity (tested):
Human
Specificity
Specificity:
This antibody detects DYRK2 at C-term.
Two isoforms of DYRK2 are known to exist; this antibody will recognize both isoforms. DYRK2 antibody will not cross-react with other DYRK family members.

Accessory Products

Proteins and/or Positive Controls

Proteins for DYRK2 (6 products)

Catalog No. Species Pres. Purity   Source  

DYRK2

DYRK2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

DYRK2

DYRK2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

DYRK2

DYRK2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

DYRK2

DYRK2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

DYRK2

DYRK2 Human
  Abnova Taiwan Corp.

DYRK2

DYRK2 Human
  Abnova Taiwan Corp.

Positive controls for DYRK2 (3 products)

Catalog No. Species Pres. Purity   Source  

DYRK2 Lysate

Western Blot: DYRK2 Lysate [NBL1-10076] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for DYRK2
  Novus Biologicals Inc.

DYRK2 overexpression lysate

DYRK2 overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.

DYRK2 overexpression lysate

DYRK2 overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.
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