NBP1-22765 Dystrophin (1808) antibody

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0.5 ml / €360.00

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Mouse anti Chicken, Fish, Mouse, Rat, Xenopus Dystrophin (1808) 1808

Product Description for Dystrophin (1808)

Mouse anti Chicken, Fish, Mouse, Rat, Xenopus Dystrophin (1808) 1808.
Presentation: Ascites
Product is tested for Paraffin Sections.

Properties for Dystrophin (1808)

Product Category Primary Antibodies
Quantity 0.5 ml
Synonyms anti-Apo dystrophin antibody, anti-BMD antibody, anti-CMD3B antibody, anti-DMD antibody, anti-DXS142 antibody, anti-DXS164 antibody, anti-DXS206 antibody, anti-DXS230 antibody, anti-DXS239 antibody, anti-DXS268 antibody, anti-DXS269 antibody, anti-DXS270 antibody, anti-DXS272 antibody, anti-Duchenne muscular dystrophy protein antibody, anti-Muscular dystrophy Duchenne and Becker types
Presentation Ascites
Reactivity Chk, Fi, Ms, Rt, Xen
Applications P
Clonality Monoclonal
Clone 1808
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

BALB/C mice were immunized with acetylcholine receptor enriched membranes and peripheral membrane proteins from Torpedo nobiliana electric organ.
Application immunohistochemistry, ABC, immunohistochemistry 1:25-1:50
Background The dystrophin gene is the largest gene found in nature, measuring 2.4 Mb. The gene was identified through a positional cloning approach, targeted at the isolation of the gene responsible for Duchenne (DMD) and Becker (BMD) Muscular Dystrophies. DMD is a recessive, fatal, X linked disorder occurring at a frequency of about 1 in 3,500 new born males. BMD is a milder allelic form. In general, DMD patients carry mutations which cause premature translation termination (nonsense or frame shift mutations), while in BMD patients dystrophin is reduced either in molecular weight (derived from in frame deletions) or in expression level. The dystrophin gene is highly complex, containing at least eight independent, tissue specific promoters and two polyA addition sites. Furthermore, dystrophin RNA is differentially spliced, producing a range of different transcripts, encoding a large set of protein isoforms. Dystrophin (as encoded by the Dp427 transcripts) is a large, rod like cytoskeletal protein which is found at the inner surface of muscle fibers. Dystrophin is part of the dystrophin glycoprotein complex (DGC), which bridges the inner cytoskeleton (F actin) and the extracellular matrix. Dystrophin is a member of the spectrin/alpha-actinin family of actin-binding, triple helix rod-containing proteins. It is absent or greatly reduced in individuals with the X-linked recessive Duchenne's muscular dystrophy disorder, as well as in mice with the mdx (murine muscular dystrophy) mutation.
Storage Store at 4C. Do not freeze.
Buffer System:
Sodium Azide
This reacts with a protein of 427 kD. This is highly specific to dystrophin and shows no cross-reaction with C-protein, a-actin, and human muscle spectrin. Dystrophin is a member of the spectrin/alpha actinin family of actin-binding protein.
Chicken, Fish, Mouse, Rat, Xenopus

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