AP06091PU-N E2F4/E2F5 antibody

See related secondary antibodies

Search for all "E2F4/E2F5"

0.1 mg / €350.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Rabbit anti Human, Mouse, Rat E2F4/E2F5

Product Description for E2F4/E2F5

Rabbit anti Human, Mouse, Rat E2F4/E2F5.
Presentation: Aff - Purified
Product is tested for Paraffin Sections.

Properties for E2F4/E2F5

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms E2F-4, E2F-5, Transcription Factor E2F4, Transcription Factor E2F5
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications P
Clonality Polyclonal
Host Rabbit
Isotype IgG
Molecular weight ~44 kDa
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Synthetic peptide, corresponding to amino acids 18-72 of Human E2F4.

Immunohistochemistry on Paraffin sections: 1/50-1/200.

Background The human retinoblastoma gene product appears to play an important role in the negative regulation of cell proliferation. Functional inactivation of Rb can be mediated either through mutation or as a consequence of interaction with DNA tumor virus encoded proteins. Of all the Rb associations described to date, the identification of a complex between Rb and the transcription factor E2F most directly implicates Rb in regulation of cell proliferation. E2F was originally identified through its role in transcriptional activation of the adenovirus E2 promoter. Sequences homologous to the E2F binding site have been found upstream of a number of genes that encode proteins with putative functions in the G1 and S phases of the cell cycle. E2F-1 is a member of a broader family of transcriptional regulators including E2F-2, E2F-3, E2F-4, E2F-5 and E2F-6, each of which forms heterodimers with a second protein, DP-1, forming an “active” E2F transcriptional regulatory complex.
Concentration 1.0 mg/ml

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Affinity chromatography using epitope-specific immunogen (> 95% pure by SDS-PAGE)
Buffer System:
Phosphate buffered saline (PBS), pH 7.2.
0.05% Sodium azide
Liquid purified Ig fraction
Aff - Purified
Species Reactivity
Species reactivity (expected):
Mouse and Rat.
Species reactivity (tested):
This antibody detects endogenous levels of E2F4 / E2F5 protein (region surrounding Leu50/83).
FocusOn and Reviews

Accessory Products

  • LinkedIn