discontinued

AM50468PU-N EBNA2 (C-term) antibody

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0.1 mg / €420.00

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Rat anti Human EBNA2 R3

Product Description for EBNA2

Rat anti Human EBNA2 R3.
Properties: (C-term)
Presentation: Purified
Product is tested for Frozen Sections, Immunoprecipitation, Western blot / Immunoblot.

Properties for EBNA2

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms Epstein-Barr nuclear antigen 2
Presentation Purified
Reactivity Hu
Applications C, IP, WB
Clonality Monoclonal
Clone R3
Host Rat
Isotype IgG2a
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q69022
Immunogen:
GST-tagged recombinant protein corresponding to human EBNA2.
GeneID:
5176198
Property C-term
Isotype control SM15P, SM15PX
Application Immunohistochemistry: A representative lot was used by an independent laboratory in IH. (Kremmer, E., et al. (1995). Virology. 208(1):336-342.)
Western Blot: 0.5 µg/mL of this antibody detected EBNA2 on 10 µg of B95-8 cell lysate.
Immunoprecipitation: A representative lot was used by an independent laboratory in IP. (Gross, H., et al. (2010). Virology. 397(2):299-310.)
Background The Epstein-Barr virus or EBV is associated with several human cancers and actively immortalizes B lymphocytes. EBV is leads to expression by a small group of viral proteins, including Epstein-Barr nuclear antigen 2 (EBNA2) which is required for immortalization. EBNA2 is a transcriptional activator belonging to the herpesviridae EBNA2 family, and performs a crucial role in activating the host resting B-cell and inducing B-cell proliferation. EBNA2 possesses an acidic activating domain with which it is able to recruit various cellular and viral involved in B-cell immortalization. Implicated in cellular phenotypic modifications, EBNA2 is known to upregulate the expression of cell surface receptors, such as CD21, MYC, and CD23, as well as upregulating viral genes such as LMP1, LMP2A, LMP2B, and EBNA1-6.
Concentration lot-specific
Storage Store undiluted at 2-8°C.
Shelf life: one year from despatch.
Format
Purification:
Protein G Chromatography
Buffer System:
0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
State:
Liquid purified Ig fraction
Purified
Specificity
Specificity:
Demonstrated to react with human cell infected with EBV.

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