TA320055 ECRG-2 (C-term) antibody

Chicken Polyclonal ECRG2 Antibody

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Search for all "ECRG-2"

0.1 mg / €371.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

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Chicken anti Human, Mouse, Rat ECRG-2

TA320055

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  • TA320055

Product Description for ECRG-2

Chicken anti Human, Mouse, Rat ECRG-2.
Properties: (C-term)
Presentation: Aff - Purified
Product is tested for Paraffin Sections, Enzyme Immunoassay, Western blot / Immunoblot.

Properties for ECRG-2

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms ECG2, Esophagus cancer-related gene 2 protein, MGC133105, MGC133106, SPINK7, Serine protease inhibitor Kazal-type 7, UNQ745/PRO1474
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications E, P, WB
Clonality Polyclonal
Host Chicken
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
P58062
Immunogen:
16 amino acid synthetic peptide near the carboxy terminus of Human ECRG2 (AP55561CP-N)
GeneID:
84651
Property C-term
Add. information Blocking peptide available: AP55561CP-N
Application Western blot: 1-2 µg/ml.
Positive Control: Human lung tissue lysate. 
Immunohistochemistry on Paraffin Sections: Start at 5 µg/ml.
Background The esophageal cancer-susceptibility gene 2 (ECRG2), also known as SPINK7, is a novel tumor suppressor gene identified from the human esophagus. It interacts directly with metallothionein 2A and urokinase-type plasminogen activator (uPA), and downregulates the activity of uPA, leading to reduced cancer cell migration, invasion and metastasis. ECRG2 forms a complex with uPA and its receptor uPAR, modifying the dynamic association of uPAR with beta1 integrins and disrupting the Src/MAP kinase pathway that normally stimulates cell migration and invasion. ECRG2 may thus represent a novel therapeutic target for cancer.
Concentration 1.0 mg/ml
General Readings
  1. Cui Y, Wang J, Zhang X, Lang R, Bi M, Guo L, et al. ECRG2, a novel candidate of tumor suppressor gene in the esophageal carcinoma, interacts directly with metallothionein 2A and links to apoptosis. Biochem Biophys Res Commun. 2003 Mar 21;302(4):904-15. PubMed PMID: 12646258.
  2. Huang G, Hu Z, Li M, Cui Y, Li Y, Guo L, et al. ECRG2 inhibits cancer cell migration, invasion and metastasis through the down-regulation of uPA/plasmin activity. Carcinogenesis. 2007 Nov;28(11):2274-81. Epub 2007 Jun 29. PubMed PMID: 17602171.
  3. Cheng X, Shen Z, Yin L, Lu SH, Cui Y. ECRG2 regulates cell migration/invasion through urokinase-type plasmin activator receptor (uPAR)/beta1 integrin pathway. J Biol Chem. 2009 Nov 6;284(45):30897-906. doi: 10.1074/jbc.M109.011213. Epub 2009 Aug 28. PubMed PMID: 19717562. (Free PMC Article available, 8 images available)
Storage

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Format
Purification:
Affinity chromatography purified via peptide column
Buffer System:
PBS containing 0.02% Sodium Azide as preservative
State:
Liquid purified Ig fraction
Aff - Purified
Species Reactivity
Species reactivity (tested):
Human, Mouse, Rat.
Specificity
Specificity:
This ECRG2 antibody is predicted not to cross-react with other ECRG family members

Accessory Products

Proteins and/or Positive Controls

Proteins for ECRG-2 (5 products)

Catalog No. Species Pres. Purity   Source  

ECRG-2

ECRG-2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

ECRG-2 (20-85, His-tag)

ECRG-2 Human Purified > 85 % by SDS - PAGE E. coli
0.25 mg / €730.00
  OriGene Technologies GmbH

ECRG-2 (20-85, His-tag)

ECRG-2 Human Purified > 85 % by SDS - PAGE E. coli
50 µg / €300.00
  OriGene Technologies GmbH

ECRG-2

ECRG-2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
  Abnova Taiwan Corp.

ECRG-2

ECRG-2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
  Abnova Taiwan Corp.

Positive controls for ECRG-2 (1 products)

Catalog No. Species Pres. Purity   Source  

SPINK7 overexpression lysate

SPINK7 overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.
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