NB100-1656 Endomorphin 1 and 2 antibody

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Rabbit anti Human, Monkey, Mouse, Porcine, Rat Endomorphin 1 and 2

Product Description for Endomorphin 1 and 2

Rabbit anti Human, Monkey, Mouse, Porcine, Rat Endomorphin 1 and 2.
Presentation: Aff - Purified
Product is tested for Paraffin Sections.

Properties for Endomorphin 1 and 2

Product Category Primary Antibodies
Quantity 50 µl
Presentation Aff - Purified
Reactivity Hu, Mky, Ms, Por, Rt
Applications P
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Synthetic peptide conjugated to BSA.
Application ELISA, immunohistochemistry, ELISA: Use at an assay dependent dilution. IHC-Fr: Use at a concentration of 3-10 ug/ml. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user., ELISA, immunohistochemistry-Fr
Background Recently, endogenous agonists for the mu-opiate receptor, were first isolated from bovine brain [Nature,386, 499 (1997)]. These are endomorphin-1; Tyr-Pro-Trp-Phe-NH2, and endomorphin-2; Tyr-Pro-Phe-Phe-NH2. The isolation of relatively large amounts of endomorphin-1 and endomorphin-2 from human brain cortex has also reported [Peptides,18, 1635 (1997)]. The immunoreactivity for endomorphin was also detected in rat brain near the mu-opiate receptor containing neurons, but the molecular form of the rat peptide has not yet been elucidated [Peptides,18, 1641 (1997)]. These observations may be considered to indicate that endomorphin-1 and 2 are common mu-opiate agonists in mammals. In addition to the originally discovered mu-opiate agonistic function, these peptides have been reported to show hypotensive activity and Ca2+ channel current inhibitory activity [Biochem. Biophys. Res. Commun.,235, 567 (1997)]. Endomorphins would be useful for the study of pain perception together with some other biological functions in the body.
General Readings General / background references:Champion HC et al. The endogenous mu-opioid receptor agonists endomorphins 1 and 2 have novel hypotensive activity in the rabbit. Biochem Biophys Res Commun 235:567-70 (1997). PubMed PMID: 9207197
Hackler L et al. Isolation of relatively large amounts of endomorphin-1 and endomorphin-2 from human brain cortex. Peptides 18:1635-9 (1997). PubMed PMID: 9437727
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Immunogen affinity purified
Buffer System:
0.05% Sodium Azide
Immunogen affinity purified
Aff - Purified
Sensitivity has been determined by ELISA. Less than 1ng of could be detected after binding to Endomorphin 2 which is conjugated to titer plate:Endomorphin 2 = 100%. Endomorphin 1 = 70%. Leu5-Enkephalin = <0.01%. Met5-Enkephalin = <0.03%.
Human, Mouse, Porcine, Primate, Rat

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