NB600-1336 Endostatin antibody

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Rabbit anti Human Endostatin


Product Description for Endostatin

Rabbit anti Human Endostatin.
Presentation: Purified
Product is tested for Western blot / Immunoblot, Paraffin Sections.

Properties for Endostatin

Product Category Primary Antibodies
Quantity 0.5 ml
Presentation Purified
Reactivity Hu
Applications P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Recombinant full length protein (Human).
Background Endostatin, which corresponds to the C terminal fragment of collagen XVIII, is a potent inhibitor of endothelial cell proliferation, migration and angiogenesis. Recent study shows that endostatin induces tyrosine kinase activity and enhanced apoptosis in FGF treated endothelial cells. Endostatin is currently being used in Phase I trails as an anti tumor agent.
General Readings General / background references:Dixelius J et al. Endostatin-induced tyrosine kinase signaling through the Shb adaptor protein regulates endothelial cell apoptosis. Blood 95:3403-11 (2000). PubMed PMID: 10828022
Hohenester E et al. Variable zinc coordination in endostatin. J Mol Biol 297:1-6 (2000). PubMed PMID: 10704302
Cirri L et al. Endostatin: a promising drug for antiangiogenic therapy. Int J Biol Markers 14:263-7 (1999). PubMed PMID: 10669957
Protein A purified
Buffer System:
10mM PBS, pH7.4, 0.2%BSA, 0.09% sodium azide
Protein A purified
Cross-reacts with Human. Not yet tested in other species.

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