AP55584PU-N EPAC1 (N-term) antibody

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Rabbit anti Human, Mouse, Rat EPAC1


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  • AP55584PU-N
  • AP55584PU-N

Product Description for EPAC1

Rabbit anti Human, Mouse, Rat EPAC1.
Properties: (N-term)
Presentation: Aff - Purified
Product is tested for Paraffin Sections, Western blot / Immunoblot.

Properties for EPAC1

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms RAPGEF3, Rap guanine nuclear exchange factor 3, bcm910, cAMPGEF-I
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Swiss Prot Num:
18 amino acid synthetic peptide near the amino terminus of human EPAC1 (AP55584CP-N)
Property N-term
Add. information Blocking peptide available: AP55584CP-N

Western blot: 1-2 μg/ml.
 Positive Control: Rat skeletal muscle tissue lysate.
Immunohistochemistry on Paraffin sections: Start at 2.5 μg/ml.

Background EPAC1, also known as Rap guanine nuclear exchange factor 3 and cAMPGEF-I, is widely expressed but most prominently in brain, heart, kidney, pancreas, spleen, ovary, thyroid and spinal cord. EPAC1 is a cAMP-binding protein with intrinsic guanine nuclear exchange factor activity that couples cAMP production to the activation of Rap, a GTPase belonging to the Ras family. This activation of Rap influences numerous cellular processes such as integrin-mediated cell adhesion, vascular endothelial barrier formation, and cardiac myocyte gap junction formation. Recently, EPAC1 has been suggested to also be involved in the cAMP-dependent regulation of ion channel formation, intracellular Ca++ signalling, ion transporter activity, and exocytosis.
Concentration 1.0 mg/ml
General Readings
  1. de Rooij J, Zwartkruis FJ, Verheijen MH, Cool RH, Nijman SM, Wittinghofer A, et al. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature. 1998 Dec 3;396(6710):474-7. PubMed PMID: 9853756.
  2. Bos JL. Epac: a new cAMP target and new avenues. Hum. Immunol. 2004; 65:282-90.
  3. Holz GG, Kang G, Harbeck M, et al. Cell physiology of cAMP sensor Epac. J. Physiol. 2006; 577:5-15. 

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Affinity chromatography purified via peptide column
Buffer System:
PBS containing 0.02% Sodium Azide as preservative
Liquid purified Ig fraction
Aff - Purified
Species Reactivity
Species reactivity (tested):
Human, Mouse, Rat
At least two isoforms of EPAC1 are known to exist. This antibody will detect both isoforms and is predicted to not cross-react with EPAC2.

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