TA319816 EPAC1 (N-term) antibody

Rabbit Polyclonal EPAC1 Antibody

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0.1 mg / €371.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Rabbit anti Human, Mouse, Rat EPAC1


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  • TA319816
  • TA319816

Product Description for EPAC1

Rabbit anti Human, Mouse, Rat EPAC1.
Properties: (N-term)
Presentation: Aff - Purified
Product is tested for Paraffin Sections, Western blot / Immunoblot.

Properties for EPAC1

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms RAPGEF3, Rap guanine nuclear exchange factor 3, bcm910, cAMPGEF-I
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Swiss Prot Num:
18 amino acid synthetic peptide near the amino terminus of human EPAC1 (AP55584CP-N)
Property N-term
Add. information Blocking peptide available: AP55584CP-N

Western blot: 1-2 μg/ml.
 Positive Control: Rat skeletal muscle tissue lysate.
Immunohistochemistry on Paraffin sections: Start at 2.5 μg/ml.

Background EPAC1, also known as Rap guanine nuclear exchange factor 3 and cAMPGEF-I, is widely expressed but most prominently in brain, heart, kidney, pancreas, spleen, ovary, thyroid and spinal cord. EPAC1 is a cAMP-binding protein with intrinsic guanine nuclear exchange factor activity that couples cAMP production to the activation of Rap, a GTPase belonging to the Ras family. This activation of Rap influences numerous cellular processes such as integrin-mediated cell adhesion, vascular endothelial barrier formation, and cardiac myocyte gap junction formation. Recently, EPAC1 has been suggested to also be involved in the cAMP-dependent regulation of ion channel formation, intracellular Ca++ signalling, ion transporter activity, and exocytosis.
Concentration 1.0 mg/ml
General Readings
  1. de Rooij J, Zwartkruis FJ, Verheijen MH, Cool RH, Nijman SM, Wittinghofer A, et al. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature. 1998 Dec 3;396(6710):474-7. PubMed PMID: 9853756.
  2. Bos JL. Epac: a new cAMP target and new avenues. Hum. Immunol. 2004; 65:282-90.
  3. Holz GG, Kang G, Harbeck M, et al. Cell physiology of cAMP sensor Epac. J. Physiol. 2006; 577:5-15. 

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Affinity chromatography purified via peptide column
Buffer System:
PBS containing 0.02% Sodium Azide as preservative
Liquid purified Ig fraction
Aff - Purified
Species Reactivity
Species reactivity (tested):
Human, Mouse, Rat
At least two isoforms of EPAC1 are known to exist. This antibody will detect both isoforms and is predicted to not cross-react with EPAC2.

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