discontinued

AP30318PU-N EphA10 antibody

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0.1 mg / €360.00

Quick Overview

Rabbit anti Human, Mouse, Rat EphA10

Product Description for EphA10

Rabbit anti Human, Mouse, Rat EphA10.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.

Properties for EphA10

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms EPH receptor A10, Ephrin type-A receptor 10, FLJ16103
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications E, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q4G0R4
Immunogen:
EphA10 antibody was raised against a 14 amino acid peptide of near the amino terminus of human EphA10. (AP30318CP-N)
GeneID:
284656
Control peptide AP30318CP-N
Add. information Blocking peptide available: blocking peptide (AP30318CP-N)
Application ELISA.
Western Blot: 1 - 2 μg/ml.
Background Eph receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell–cell communication regulating cell attachment, shape, and mobility of neuronal and endothelial cells in central nervous system function and in development. Eph receptors can be divided into two subgroups: EphA and EphB. In mammals, the EphA class consists of eight members (EphA 1-7 and 10) that in general bind to ephrin-A members linked to the cell membrane through a glycosylphosphatidylinositol linkage. The EphB class consists of six members (EphB 1-6) that in general bind ephrin-B members that transverse the cell membrane. The Ephrin / EPH signaling pathway networks with the WNT signaling pathway during embryogenesis, tissue regeneration, and carcinogenesis. Recent studies show that Eph/EFN might be relevant in normal B-cell biology and could represent new potential prognostic markers and therapeutic targets for CLL.
General Readings
  1. Flanagan JG, Vanderhaeghen P. The ephrins and Eph receptors in neural development. Annu Rev Neurosci. 1998;21:309-45. PubMed PMID: 9530499.
  2. Frisén J, Holmberg J, Barbacid M. Ephrins and their Eph receptors: multitalented directors of embryonic development. EMBO J. 1999 Oct 1;18(19):5159-65. PubMed PMID: 10508149. (Free PMC Article available)
  3. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. Cell. 1997 Aug 8;90(3):403-4. PubMed PMID: 9267020.
  4. Holder N, Klein R. Eph receptors and ephrins: effectors of morphogenesis. Development. 1999 May;126(10):2033-44. PubMed PMID: 10207129.
Storage Store the antibody undiluted at 2-8°C.
Shelf life: one year from despatch.
Format
Purification:
Affinity chromatography purified via peptide column
Buffer System:
PBS containing 0.02% sodium azide.
State:
Liquid purified Ig fraction
Aff - Purified
Specificity
Specificity:
This antibody reacts to EphA10.
Species:
Human, Mouse, Rat.
Gene ID 284656

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