discontinued

AM33244SU-N Epstein Barr Virus / EBV (LMP1) antibody

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Search for all "Epstein Barr Virus / EBV"

0.1 ml / €380.00

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Mouse anti Epstein Barr Virus / EBV CS1/CS2/CS3/CS4

AM33244SU-N

Product Description for Epstein Barr Virus / EBV

Mouse anti Epstein Barr Virus / EBV CS1/CS2/CS3/CS4.
Properties: (LMP1)
Presentation: Supernatant
Product is tested for Paraffin Sections, Frozen Sections.

Properties for Epstein Barr Virus / EBV

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms HHV-4, HHV4
Presentation Supernatant
Applications C, P
Clonality Monoclonal
Clone CS1/CS2/CS3/CS4
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Recombinant fusion protein of bacterial beta-galactosidase and EBV LMP-1. 
Spleen cells from immunised mice were fused with cells of the mouse X63-Ag8.653 myeloma cell line.
Property LMP1
Application
Immunohistochemistry on Paraffin Sections:
1/100-1/200.
Requires protein digestion pre-treatment of paraffin sections e.g. trypsin or pronase.
Background EBV is a human herpesvirus that establishes a life-long persistence in the host. The virus infects the vast majority of the world's adult population and is well known for its association with a broad spectrum of benign and malignant diseases, including infectious mononucleosis, Burkitt's lymphoma, nasopharyngeal carcinoma, and is causally associated with lymphoid and epithelial malignancies, including post-transplant lymphoproliferative disorders, Hodgkin's disease, anaplastic nasopharyngeal carcinoma and gastric carcinomas. Latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) is a transforming protein that affects multiple cell signalling pathways and contributes to EBV-associated oncogenesis. LMP1 can be expressed in some states of EBV latency, and significant induction of full-length LMP1 is also observed frequently during virus reactivation into the lytic cycle. LMP1 is critical for EBV-infected cell activation, adhesion and survival, and is usually expressed in the malignant cells.
General Readings
  1. Murray PG, Young LS, Rowe M, Crocker J. Immunohistochemical demonstration of the Epstein-Barr virus-encoded latent membrane protein in paraffin sections of Hodgkin's disease. J Pathol. 1992 Jan;166(1):1-5. PubMed PMID: 1311374.
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Preservatives:
15mM Sodium Azide
State:
Liquid Tissue Culture Supernatant
Supernatant
Specificity
Specificity:
This Mouse anti Epstein-Barr Virus LMP antibody, Clone CS1/CS2/CS3/CS4 is a cocktail of 4 antibodies recognising different epitopes of Epstein Barr Virus Latent Membrane Protein (LMP).
Mouse anti Epstein-Barr Virus LMP antibody, Clone CS1/CS2/CS3/CS4 stains EBV positive lymphoblastoid cell lines and EBV infected B cells in infectious mononucleosis.

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