AP08087PU-N ERBB3 / HER3 antibody

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0.1 mg / €320.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

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Rabbit anti Human, Mouse, Rat ERBB3 / HER3

AP08087PU-N

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  • AP08087PU-N

Product Description for ERBB3 / HER3

Rabbit anti Human, Mouse, Rat ERBB3 / HER3.
Presentation: Aff - Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot, Paraffin Sections.

Properties for ERBB3 / HER3

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms ERBB-3, HER-3, Proto-oncogene-like protein c-ErbB-3, Receptor tyrosine-protein kinase erbB-3, Tyrosine kinase-type cell surface receptor HER3, c-erbB-3
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications ICC/IF, P, WB
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P21860
Immunogen:
Peptide sequence around amino acids 1326~1330 (P-D-Y-W-H) derived from Human Her3/ErbB3.
GeneID:
2065
Add. information Molecular Weight: 185 kDa
Application Western blot: 1/500-1/1000.
Incubate membrane with diluted antibody in 5% nonfat milk, 1xTBS, 0.1% Tween-20 at 4°C with gentle shaking overnight.
Immunofluorescence: 1/100-1/200.
Immunohistochemistry on Paraffin-Embedded Sections: 1/50-1/100.
Background The ErbB3 gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain. It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, bladder and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterized.
Concentration 1.0 mg/ml
General Readings
  1. Holbro, T. et al. (2003) Proc. Natl. Acad. Sci. USA 100, 8933-8938.
  2. Kobayashi, M. et al. (2003) Oncogene 22, 1294-1301.
  3. Kim, H.H. et al. (1994) J. Biol. Chem. 269, 24747-24755.
  4. Yarden, Y. and Sliwkowski, M.X. (2001) Nature Rev. Mol. Cell. Biol. 2, 127-137.
Storage Store the antibody (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Shelf life: One year from despatch.
Format
Purification:
Immunoaffinity Chromatography using epitope-specific immunogen.
Buffer System:
PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% Sodium Azide and 50% Glycerol.
State:
Liquid purified Ig fraction.
Aff - Purified
Specificity
Specificity:
This antibody detects endogenous levels of total Her3/ErbB3 protein.
Species:
Human, Mouse and Rat.
Gene ID 2065
FocusOn and Reviews
Reviews:

Accessory Products

Proteins and/or Positive Controls

Proteins for ERBB3 / HER3 (16 products)

Catalog No. Species Pres. Purity   Source  

ERBB3 / HER3 (transcript variant 1)

ERBB3 / HER3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

ERBB3 / HER3 (transcript variant s)

ERBB3 / HER3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

ERBB3 / HER3 (transcript variant 1)

ERBB3 / HER3 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

ERBB3 / HER3 (C-term DDK/His tag, transcript variant 1)

ERBB3 / HER3 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

ERBB3 / HER3 (full length, C-term DDK tag, transcript variant 1)

ERBB3 / HER3 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
SF9 cells
20 µg / €399.00
  OriGene Technologies, Inc.

ERBB3 / HER3 (C-term DDK tag, transcript variant 1)

ERBB3 / HER3 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
SF9 cells
20 µg / €399.00
  OriGene Technologies, Inc.

ERBB3 / HER3

ERBB3 / HER3 Human Purified >95.0% as determined by both RP-HPLC and SDS-PAGE analysis E. coli
  OriGene Technologies GmbH

ERBB3 / HER3

ERBB3 / HER3 Human Purified >95.0% as determined by both RP-HPLC and SDS-PAGE analysis E. coli
  OriGene Technologies GmbH

ERBB3 / HER3

ERBB3 / HER3 Human Purified >95.0% as determined by both RP-HPLC and SDS-PAGE analysis E. coli
  OriGene Technologies GmbH

ERBB3 / HER3 (20-643, His-tag)

ERBB3 / HER3 Human Purified > 80 % by SDS - PAGE
0.25 mg / €940.00
  OriGene Technologies GmbH

ERBB3 / HER3 (20-643, His-tag)

ERBB3 / HER3 Human Purified > 80 % by SDS - PAGE
50 µg / €300.00
  OriGene Technologies GmbH

ERBB3 / HER3

ERBB3 / HER3 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

ERBB3 / HER3

ERBB3 / HER3 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

ERBB3 / HER3

ERBB3 / HER3 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

ERBB3 / HER3

ERBB3 / HER3 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

ERBB3 / HER3

ERBB3 / HER3 Human
  Abnova Taiwan Corp.

Positive controls for ERBB3 / HER3 (4 products)

Catalog No. Species Pres. Purity   Source  

ERBB3 Lysate(Denatured)

ERBB3 Lysate(Denatured)
  Abnova Taiwan Corp.

ERBB3 overexpression lysate

ERBB3 overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.

ERBB3 overexpression lysate

ERBB3 overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.

ERBB3 overexpression lysate

ERBB3 overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.
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