AM05521PU-N ERCC1 antibody

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Mouse anti Human ERCC1 3H11


Product Description for ERCC1

Mouse anti Human ERCC1 3H11.
Presentation: Purified
Product is tested for Western blot / Immunoblot.

Properties for ERCC1

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Purified
Reactivity Hu
Applications WB
Clonality Monoclonal
Clone 3H11
Host Mouse
Isotype IgG2a
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Full length, his-tagged recombinant ERCC1.
Isotype control AM03096PU-N
Application Western Blot.
Background The mammalian ERCC1 (Excision Repair Cross Complementing) polypeptide is required for nucleotide excision repair (NER) of damaged DNA and is homologous to Saccharomyces cerevisiae RAD10, which functions in repair and mitotic intrachromosomal recombination. NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells XPG cleaves 3' of the DNA lesion while the ERCC1 XPF complex makes the 5'incision. Elevated levels of ERCC1 have also been reported in Cisplatin resistant cells.
Caution (A full Health and Safety assessment is available upon request) This product contains sodium azide : a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Concentration 1.0 mg/ml
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Affinity chromatography on Protein A
Buffer System:
Phosphate buffered saline containing 0.09% Sodium Azide
Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Liquid purified IgG
This antiobdy recognises ERCC1 protein, which is involved in nucleotide excision repair.

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