discontinued

DM3079 ERCC1 antibody

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0.1 mg / €280.00

Quick Overview

Mouse anti Human ERCC1 3H11

Product Description for ERCC1

Mouse anti Human ERCC1 3H11.
Presentation: Purified
Product is tested for Immunoprecipitation, Western blot / Immunoblot.

Properties for ERCC1

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms AB43
Presentation Purified
Reactivity Hu
Applications IP, WB
Clonality Monoclonal
Clone 3H11
Host Mouse
Isotype IgG2a
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Biomeda

Datasheet Extract

Immunogen
Immunogen:
Full length recombinant human ERCC1 protein.
Isotype control AM03096PU-N
Application Immunoprecipitation: Denatured verified; Use Protein A; Ab 2µg/mg protein lysate. Western Blotting: Ab 1-2µg/ml for 2hrs at RT. Not suitable for Immunohistology. Recommended positive control: A431 or HeLa Cells. Other applications not tested. Optimal dilutions of this antibody are dependent on conditions and should be determined by the user.
Concentration 0.2 mg/ml
General Readings
  1. Miura M, Nakamura S, Sasaki T, Takasaki Y, Shiomi T, Yamaizumi M. Roles of XPG and XPF/ERCC1 endonucleases in UV-induced immunostaining of PCNA in fibroblasts. Exp Cell Res. 1996 Jul 10;226(1):126-32. PubMed PMID: 8660947.
  2. Hayashi T, Takao M, Tanaka K, Yasui A. ERCC1 mutations in UV-sensitive Chinese hamster ovary (CHO) cell lines. Mutat Res. 1998 Jun;407(3):269-76. PubMed PMID: 9653453.
  3. de Laat WL, Appeldoorn E, Jaspers NG, Hoeijmakers JH. DNA structural elements required for ERCC1-XPF endonuclease activity. J Biol Chem. 1998 Apr 3;273(14):7835-42. PubMed PMID: 9525876.
  4. de Laat WL, Sijbers AM, Odijk H, Jaspers NG, Hoeijmakers JH. Mapping of interaction domains between human repair proteins ERCC1 and XPF. Nucleic Acids Res. 1998 Sep 15;26(18):4146-52. PubMed PMID: 9722633. (Free PMC Article available)
  5. Lee-Kwon W, Park D, Bernier M. Involvement of the Ras/extracellular signal-regulated kinase signalling pathway in the regulation of ERCC-1 mRNA levels by insulin. Biochem J. 1998 Apr 15;331 ( Pt 2):591-7. PubMed PMID: 9531502. (Free PMC Article available)
  6. Lee-Kwon W, Park D, Bernier M: Nucleotide excision repair is not required for the antiapoptotic function of insulin
Storage Store the antibody at 4°C. Do not freeze! Shelf life: one year from despatch.
Format
State:
Purified
Specificity
Specificity:
The mammalian ERCC1 (Excision Repair Cross Complementing) polypeptide is required for nucleotide excision repair (NER) of damaged DNA and is homologous to Saccharomyces cerevisiae RAD10, which functions in repair and mitotic intrachromosomal recombination. Cellular Localization: nuclear.

Mol. Wt. of Antigen: 33-36kD

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