NB110-56969 ERK1 / ERK2 (pT-E-pY Motif) antibody

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Rabbit anti Human ERK1 / ERK2 E337


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  • NB110-56969

Product Description for ERK1 / ERK2

Rabbit anti Human ERK1 / ERK2 E337.
Properties: (pT-E-pY Motif)
Presentation: Aff - Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Paraffin Sections, Western blot / Immunoblot.

Properties for ERK1 / ERK2

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms ERK-1/ERK-2, Extracellular signal regulated kinase 1/2, Insulin stimulated MAP2 kinase, MAPK1/MAPK2, Microtubule associated protein 2 kinase, Mitogen activated protein kinase 1/2/3, P42/P44-MAPK
Presentation Aff - Purified
Reactivity Hu
Applications ICC/IF, P, WB
Clonality Monoclonal
Clone E337
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Property pT-E-pY Motif
Isotype control PP501P
Add. information Research Areas: Lipid and Metabolism, Cancer
Application Immunocytochemistry, immunohistochemistry, Western Blot, Immunohistochemistry, Western Blot and Immunocytochemistry, immunohistochemistry 1:50 , Western Blot 1:500, Immunocytochemistry 1:250
Background Extra cellular signal-regulated kinases Erk1 (p44 MAPK) and Erk2 (p42 MAPK) Serine/Threonine proteine kinase are part of a subfamily of mitogen-activated protein kinases that participate in diverse cellular functions, including the regulation of cell growth, differentiation, apoptosis and signal transduction (1,2,3) The simultaneous tyrosine/threonine phosphorylation of ERK1 and ERK2 results in their activation. Although ERK1and ERK2 resemble one another closely in sequence and are activated by similar pathways, they appearto have different tissue distributions(4) and show differential phosphorylation of potential intracellular substrates(5)
General Readings
  1. Charest DL, Mordret G, Harder KW, Jirik F, Pelech SL. Molecular cloning, expression, and characterization of the human mitogen-activated protein kinase p44erk1. Mol Cell Biol. 1993 Aug;13(8):4679-90. PubMed PMID: 7687743. (Free PMC Article available)
  2. Marshall CJ. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell. 1995 Jan 27;80(2):179-85. PubMed PMID: 7834738.
  3. Brott BK, Alessandrini A, Largaespada DA, Copeland NG, Jenkins NA, Crews CM, et al. MEK2 is a kinase related to MEK1 and is differentially expressed in murine tissues. Cell Growth Differ. 1993 Nov;4(11):921-9. PubMed PMID: 8297798.
  4. Boulton TG, Cobb MH. Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies. Cell Regul. 1991 May;2(5):357-71. PubMed PMID: 1654126. (Free PMC Article available)
Storage Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer System:
0.01% Sodium Azide
Aff - Purified
A synthetic phospho-peptide corresponding to residues surrounding Thr202 and Tyr204 of human ERK1 was used as immunogen. The only detects ERK1 phosphorylated on Threonine 202 and Tyrosine 204, or ERK2 phosphorylated on Threonine 185 and Tyrosine 187.
Human, Mouse (-), Rat (-)

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