discontinued

NB500-141 ERK1 / ERK2 (pT-E-pY Motif) antibody

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Search for all "ERK1 / ERK2"

0.1 ml / €380.00

Quick Overview

Rabbit anti Human, Rat ERK1 / ERK2

Product Description for ERK1 / ERK2

Rabbit anti Human, Rat ERK1 / ERK2.
Properties: (pT-E-pY Motif)
Presentation: Purified
Product is tested for Paraffin Sections, Western blot / Immunoblot.

Properties for ERK1 / ERK2

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms ERK-1/ERK-2, Extracellular signal regulated kinase 1/2, Insulin stimulated MAP2 kinase, MAPK1/MAPK2, Microtubule associated protein 2 kinase, Mitogen activated protein kinase 1/2/3, P42/P44-MAPK
Presentation Purified
Reactivity Hu, Rt
Applications P, WB
Clonality Polyclonal
Host Rabbit
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
NB 500-141 was raised against a synthetic phosphopeptide corresponding to amino acid residues surrounding the phosphorylated Thr202/Tyr204.
Property pT-E-pY Motif
Add. information Research Areas: Cancer, Lipid and Metabolism
Application Western Blot, NB 500-141 can be used in Western blot where a band is seen at ~ 42-44 kDa, representing ERK 1/2. , Western Blot 1:1000
Background The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated through two closely related MAP kinases (p44 and p42), designated ERK 1 (extracellular-signal related kinase 1) and ERK 2, respectively. ERK proteins are regulated by dual phosphorylation at specific tyrosine and threonine sites, which is required for full enzymatic activation. Once activated, MAP kinases phosphorylate downstream components on serine and threonine. Upstream MAP kinase regulators include MEK and Raf-1.
Storage Store at -20C. Avoid freeze-thaw cycles.
Format
Buffer System:
No Preservative
State:
Purified
Specificity
Specificity:
NB500-141 is specific for the 42/44 kD ERK 1/2 protein, phosphorylated at Thr202/Tyr204. The specificity is defined based on NB500-141's specific immunolabeling in Western blots. This labeling is blocked by the phosphopeptide but not the dephosphopepti
Species:
Human, Mouse, Rat, Xenopus

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