NB600-1070 ERK1 / ERK2 (pT-E-pY Motif) antibody

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0.1 ml / €410.00

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Rabbit anti Human, Mouse, Rat ERK1 / ERK2

Product Description for ERK1 / ERK2

Rabbit anti Human, Mouse, Rat ERK1 / ERK2.
Properties: (pT-E-pY Motif)
Presentation: Serum
Product is tested for Paraffin Sections, Western blot / Immunoblot.

Properties for ERK1 / ERK2

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms ERK-1/ERK-2, Extracellular signal regulated kinase 1/2, Insulin stimulated MAP2 kinase, MAPK1/MAPK2, Microtubule associated protein 2 kinase, Mitogen activated protein kinase 1/2/3, P42/P44-MAPK
Presentation Serum
Reactivity Hu, Ms, Rt
Applications P, WB
Clonality Polyclonal
Host Rabbit
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Synthetic phospholyrated peptide (KLH coupled) corresponding to residues around Thr202/Tyr204 of human p44 MAP kinase (Erk1 and Erk2)
Property pT-E-pY Motif
Add. information Research Areas: Cancer, Lipid and Metabolism
Application Western Blot, Predicted molecular weight: 43 kDa. , Western Blot 1/5000
Background ERK (extracellular signal regulated kinase), also known as MAPK (mitogen activated protein kinase) has two closely related isoforms of 44 kDa and 42 kDa, respectively. These kinases belong to a family of serine/threonine kinases that are activated upon treatment of cells with a large variety of stimuli including mitogens, hormones, growth factors, cytokines, and bioactive peptides. Cell stimulation induces the activation of a signaling cascade, the downstream effects of which have been linked to the regulation of cell growth and differentiation as well as the cytoskeleton. ERK1 and ERK2 are phosphorylated within the activation loop on both a Threonine and a Tyrosine residue (within a Thr-Glu-Tyr motif) by MEKs (MAPK/ERK kinases), thereby greatly elevating the activity of ERK1&2.
Concentration 1 mg/ml
General Readings General / background references:Smalley KS A pivotal role for ERK in the oncogenic behaviour of malignant melanoma? Int J Cancer 104:527-32 (2003). PubMed PMID: 12594806
Johnson GL & Lapadat R Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298:1911-2 (2002). PubMed PMID: 12471242
Kolch W Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem J 351 Pt 2:289-305 (2000). PubMed PMID: 11023813
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Whole antisera
Buffer System:
No Preservative
Whole antisera
This recognises ERK1 phosphorylated at Thr202 and ERK1 phosphorylated at Tyr204.
Human, Mouse, Rat

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