NBP1-19924 ERK1 / ERK2 pThr202/pTyr204 antibody

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0.1 mg / €420.00
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Rabbit anti Human, Mouse, Rat ERK1 / ERK2

NBP1-19924

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  • NBP1-19924

Product Description for ERK1 / ERK2

Rabbit anti Human, Mouse, Rat ERK1 / ERK2.
Properties: pThr202/pTyr204
Presentation: Aff - Purified
Product is tested for Paraffin Sections, Western blot / Immunoblot.

Properties for ERK1 / ERK2

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms ERK-1, ERT2, Extracellular signal-regulated kinase 1, Insulin-stimulated MAP2 kinase, MAP kinase 3, MAP kinase isoform p44, MAPK 3, Microtubule-associated protein 2 kinase, Mitogen-activated protein kinase 1, Mitogen-activated protein kinase 3, PRKM3, p44-ERK1, p44-MAPK
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications P, WB
Clonality Polyclonal
Host Rabbit
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Property pThr202/pTyr204
Add. information Research Areas: Lipid and Metabolism, Cancer
Application immunohistochemistry, Western Blot, This antibody is useful for Western Blot and Immunohistochemistry. Western blot analysis of p-ERK1/2 (T202/Y204) antibody in extracts from Jurkat PMA cells . Immunohistochemistry analyzes of p-ERK1/2 (T202/Y204) antibody in paraffin-embedded human breast carcinoma tissue., Western Blot 1:500-1:1000, immunohistochemistry 1:50-1:200,
Background The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated through two closely related MAP kinases, p44 and p42, designated extracellular-signal related kinase 1 (ERK 1) and ERK 2, respectively. ERK proteins are regulated by dual phosphorylation at Tyrosine 204 and 187 and Threonine 177 and 160 residues mapping within a characteristic Thr-Glu-Tyr motif. Phosphorylation at both the Threonine 202 and Tyrosine 204 residues of ERK 1 and Threonine 185 and Tyrosine 187 residues of ERK 2 is required for full enzymatic activation. The structural consequences of dual phosphorylation in ERK 2 include active site closure, alignment of key catalytic residues that interact with ATP, and remodeling of the activation loop. In response to activation, MAP kinases phosphorylate downstream components on serine and threonine. Upstream MAP kinase regulators include MAP kinase kinase (MEK), MEK kinase and Raf-1. The ERK family has three additional members: ERK 3, ERK 5 and ERK 6.
Concentration 1 mg/ml
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Format
Purification:
Affinity purified
Buffer System:
No Preservative
Purity:
Affinity purified
State:
Aff - Purified
Specificity
Specificity:
p-ERK1/2 (T202/Y204) detects endogenous levels of p-ERK1/2 protein.
Species:
Human, Mouse, Rat

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