AP23349PU-N Estrogen receptor beta (N-term) antibody

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0.1 mg / €390.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

Quick Overview

Rabbit anti Human, Mouse, Rat Estrogen receptor beta

AP23349PU-N

Product Description for Estrogen receptor beta

Rabbit anti Human, Mouse, Rat Estrogen receptor beta.
Properties: (N-term)
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for Estrogen receptor beta

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms ER-beta, ESR2, ESTRB, NR3A2, Nuclear receptor subfamily 3 group A member 2
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q92731
Immunogen:
A synthetic peptide mapping at the N-terminal of human ERβ
GeneID:
2100
Remarks:
Sequence is different from the related mouse sequence by four amino acids.
Property N-term
Application Western blot: At 0.5-1μg/ml with the appropriate system to detect ERβ in cells and tissues.
Background Estrogen receptor-beta, referred to as ESR2, is a member of the superfamily of nuclear receptors,which can transduce extracellular signals into transcriptional responses. This gene is mapped to 14q and comprises 8 exons spanning approximately 40 kb. ESR2 is expressed in multiple tissues, including developing spermatids of the testis and in ovarian granulosa cells. ESR-beta is homologous to the previously identified ESR-alpha and has an overlapping but nonidentical tissue distribution. The DNA-binding domain of ESR-beta is 96% conserved compared to ESR, and the ligand-binding domain shows 58% conserved residues. ESR-beta is expressed in human thymus, spleen, ovary, and testis. Rat ESR-beta is expressed in rat prostate and ovary and is homologous to rat ESR (95% conserved DNA-binding domain; 55% conserved ligand-binding domain). ESR2 mRNA was coexpressed with ESR1 and its splice variants in 60% of prolactinomas, 100% of mixed growth hormone /prolactin tumors, and 29% of gonadotroph tumors. ESR2 gene expression was not limited to ESR1-positive tumor subtypes, however, and was also found in 100% of null cell tumors, 80% of somatotroph tumors, and 60% of corticotroph tumors.
Storage Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Immunogen affinity purified
Buffer System:
5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3
State:
Lyophilized Ig fraction
Aff - Purified
Reconstitution:
0.2ml of distilled water will yield a concentration of 500μg/ml.
Species Reactivity
Species reactivity (tested):
Human, mouse, rat
Specificity
Specificity:
This antibody detects Estrogen receptor beta.
Gene ID 2100
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Accessory Products

Proteins and/or Positive Controls

Proteins for Estrogen receptor beta (6 products)

Catalog No. Species Pres. Purity   Source  

Estrogen receptor beta (full length, C-term DDK tag)

Estrogen receptor beta Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
SF9 cells
20 µg / €411.00
  OriGene Technologies, Inc.

Estrogen receptor beta

Estrogen receptor beta Human
  Abnova Taiwan Corp.

Estrogen receptor beta

Estrogen receptor beta Human in vitro transl.
  Abnova Taiwan Corp.

Estrogen receptor beta

Estrogen receptor beta Human in vitro transl.
  Abnova Taiwan Corp.

Estrogen receptor beta

Estrogen receptor beta Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Estrogen receptor beta

Estrogen receptor beta Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Positive controls for Estrogen receptor beta (1 products)

Catalog No. Species Pres. Purity   Source  

Estrogen Receptor beta Lysate

Western Blot: Estrogen Receptor beta Lysate [NBL1-10345] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for ESR2
  Novus Biologicals Inc.
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