TA327231 Exostosin-1 antibody

EXT1 Rabbit Polyclonal Antibody

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0.1 mg / €335.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

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Rabbit anti Human, Mouse, Rat Exostosin-1

TA327231

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  • TA327231

Product Description for Exostosin-1

Rabbit anti Human, Mouse, Rat Exostosin-1.
Presentation: Purified

Properties for Exostosin-1

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms EXT1, Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, Multiple exostoses protein 1, Putative tumor suppressor protein EXT1
Presentation Purified
Reactivity Hu, Ms, Rt
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q16394
Immunogen:
Recombinant protein of human EXT1.
GeneID:
2131
Application WB 1:500 - 1:2000
IHC 1:50- 1:200
Background Hereditary multiple exostoses (EXT) is an autosomal domint disorder characterized by the formation of cartilage-capped tumors (exostoses) that develop from the growth plate of endochondral bone. This condition can lead to skeletal abnormalities, short stature and malignt transformation of exostoses to chondrosarcomas or osteosarcomas. Linkage alyses have identified three different genes for EXT, EXT1 on 8q24.1, EXT2 on 11p11-13 and EXT3 on 19p, a family of tumor suppressor genes. Most EXT cases have been attributed to missense or frameshift mutations, which lead to loss of function of the EXT genes. EXT1 is an ER-resident type II transmembrane glycoprotein and a heparan sulphate polymerase with both D-glucuronyl and N-acetyl-D-glucosaminoglycan transferase activities. Expression of EXT1 in cells results in the alteration of the synthesis and display of cell surface heparan sulfate glycosaminoglycans. EXT1 mutations have been identified in multiple types of human tumors.
Format
Purification:
Affinity purification
Buffer System:
Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
State:
Purified

Accessory Products

Proteins and/or Positive Controls

Proteins for Exostosin-1 (5 products)

Catalog No. Species Pres. Purity   Source  

Exostosin-1

Exostosin-1 Human
  Abnova Taiwan Corp.

Exostosin-1

Exostosin-1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
  Abnova Taiwan Corp.

Exostosin-1

Exostosin-1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
  Abnova Taiwan Corp.

Exostosin-1

Exostosin-1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Exostosin-1

Exostosin-1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Positive controls for Exostosin-1 (2 products)

Catalog No. Species Pres. Purity   Source  

EXT1 Lysate

Western Blot: Exostosin 1 Lysate [NBL1-10391] - Western Blot experiments.  Left-Control; Right -Over-expression Lysate for Exostosin 1.
  Novus Biologicals Inc.

EXT1 Lysate

Western Blot: Exostosin 1 Lysate [NBL1-10393] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for Exostosin 1
  Novus Biologicals Inc.
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