NB100-79941 EZH1 + EZH2 antibody

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Rabbit anti Human EZH1 + EZH2 EP1408Y


Product Description for EZH1 + EZH2

Rabbit anti Human EZH1 + EZH2 EP1408Y.
Product is tested for Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Western blot / Immunoblot, Flow Cytometry.

Properties for EZH1 + EZH2

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms EC, ENX-1, ENX-2, ENX1, EZH-1, EZH-2, EZH1, EZH2, Enhancer of zeste homolog 1, Enhancer of zeste homolog 2, KIAA0388, KMT-6, KMT6, Lysine N-methyltransferase 6, Polycomb protein EZH2
Reactivity Hu
Applications F, ICC/IF, IP, WB
Clonality Monoclonal
Clone EP1408Y
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

A synthetic peptide corresponding to residues near the C-terminus of human Ezh 1/2 was used as an immunogen.
Application Western Blot 1:500,Immunocytochemistry 1:50-100,immunoprecipitation 1:20,flow cytometry / FACS analysis 1:30
Background Enhancer of Zeste homolog 2 (Ezh2) is a methyltransferase that plays an important role in many biological processes through its ability to trimethylate lysine 27 in histone H3. It has been shown that Akt phosphorylates Ezh2 at serine 21 and suppresses its methyltransferase activity by impeding Ezh2 binding to histone H3, which results in a decrease of lysine 27 trimethylation and derepression of silenced genes (1). Ezh2 interacts specifically with Vav both in vitro and in vivo. ENX-1 represents the human homolog of the Drosophila Enhancer of zeste gene, a member of the Polycomb group of genes, which are transcriptional regulators of homeobox gene expression.(2). Ezh2 is an essential epigenetic regulator of embryonic development in mice, but its role in the adult organism is unknown. High expression of Ezh2 in developing murine lymphocytes suggests Ezh2 involvement in lymphopoiesis. Data suggest Ezh2-dependent histone H3 methylation as a novel regulatory mechanism controlling Igh rearrangement during early murine B cell development (3).
General Readings
  1. Hobert O, et al. Mol Cell Biol. 16(6):3066-73, 1996. 2. Cha TL, et al. Science 310(5746):306-10, 2005. 3. Su IH, et al. Nat Immunol 4(2):124-31, 2003.
Storage Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
This antibody is reactive against Human

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