SP6283P F1A alpha / FEM1 beta (609-622) antibody

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50 µg / €210.00

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Rabbit anti Human, Mouse F1A alpha / FEM1 beta (609-622)


Product Description for F1A alpha / FEM1 beta (609-622)

Rabbit anti Human, Mouse F1A alpha / FEM1 beta (609-622).
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for F1A alpha / FEM1 beta (609-622)

Product Category Primary Antibodies
Quantity 50 µg
Presentation Aff - Purified
Reactivity Hu, Ms
Applications WB
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer AnaSpec

Datasheet Extract

Rabbit anti-F1Aα polyclonal antibody was raised against a peptide (DINYQDQIPRTLEE) corresponding to amino acids 609 to 622 of human F1Aα ď? (1). This sequence is identical to the corresponding sequence of mouse FEM1β ď? (2).
Application This polyclonal antibody can be used for detection of F1Aα by
Western blot at 0.5 to 1 μg/ml. Mouse liver tissue lysate can be used as
positive control and an approximately 70 kDa band can be detected.
Other applications not tested. Optimal dilutions of this antibody are dependent on conditions and should be determined by the user.
Concentration 0.5 mg/ml
General Readings 1. Chan SL, Tan KO, Zhang L, Yee KS, Ronca F, Chan MY, Yu VC. F1Aalpha, a death receptor-binding protein homologous to the Caenorhabditis elegans sex-determining protein, FEM-1, is a caspase substrate that mediates apoptosis.
J Biol Chem. 1999;274(45):32461-8.
2. Ventura-Holman T, Maher JF. Sequence, organization, and expression of the human FEM1B gene. Biochem Biophys Res Commun 2000;267(1):317-20
3. Chan SL, Yee KS, Tan KM, Yu VC. The Caenorhabditis elegans sex determination protein FEM-1 is a CED-3 substrate that associates with CED-4 and mediates apoptosis in mammalian
Storage Store the antibody at 4°C. Shelf life: one year from despatch.
Aff - Purified
Fas and tumor necrosis factor receptor 1 (TNFR1) are two prototype members in the death receptor family. A novel protein that associates with the intracellular domains of Fas and TNFR1 was recently identified and designated F1Aα and FEM1β (1,2). F1Aα/FEM1β is the homologue of C. elegans sex determining protein FEM-1 (1,2). FEM-1/F1Aα is cleaved by CED-3 and caspase (3). FEM-1/F1Aα associates with CED-4 and its mammalian homologue Apaf-1 (3). Overexpression of F1Aα induces apoptosis. F1Aα is therefore a novel member of the death receptor associated protein that mediates apoptosis. F1Aα is expressed in a variety of human and mouse tissues (1,2). Reacts with human, mouse and rat.

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