bs-1349R FADD pSer194 antibody

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Rabbit anti Rat FADD


Product Description for FADD

Rabbit anti Rat FADD.
Properties: pSer194
Presentation: Purified
Product is tested for Paraffin Sections, Western blot / Immunoblot.

Properties for FADD

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms FADD phospho S194, FADD protein, Fas TNFRSF6 associated via death domain, Fas associated via death domain, Fas associating death domain containing protein, Fas associating protein, Fas associating protein with death domain, GIG 3, GIG3, Growth inhibiting gene 3 protein, H sapiens mRNA for mediator of receptor induced toxicity, MGC8528, MORT 1, MORT1., Mediator of receptor induced toxicity, P-Fas-associated protein with death domain, p-FADD phospho S194
Presentation Purified
Reactivity Rt
Applications P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer Bioss, Inc.

Datasheet Extract

Swiss Prot Num:
KLH conjugated synthetic phosphopeptide derived from rat protein FADD around the phosphorylation site of Ser194.
Property pSer194
Application WB(1:100-1000)
Background FADD (Fas Associated Death Domain) is an apoptosis adapter molecule enabling transduction of the apoptosis signal initiated via the FasL/Fas receptor interaction. The protein contains a C terminal death domain that interacts with the Fas receptor death domain. The N terminus contains a death effectors domain (DED) which recruits caspase to the death inducing signaling complex (DISC) and initiates the apoptotic caspase cascade. Recruitment of Caspase 8 to the Fas receptor results in oligomerization of the Caspase 8 protein, which in turn drives its autoactivation through self-cleavage. Activated Caspase 8 then activates other downstream caspases including Caspase 9, thereby commiting the cell to undergo apoptosis. FADD is implicated in non-apoptotic cellular pathways such as the regulation of cell cycle machinery in T lymphocytes. This is connected to the phosphorylation state of FADD and to the FasL/TRAIL induced transcriptional activation of cfos protooncogene. FADD also interacts with the hepatitis C virus core protein in the HEK 293 cell line.
Storage Store at -20°C for 12 months.
Purified by Protein A.
Buffer System:
Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.

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