NB100-81919 FAK antibody

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0.1 mg / €380.00

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Rabbit anti Human, Rat FAK


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  • NB100-81919

Product Description for FAK

Rabbit anti Human, Rat FAK.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for FAK

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms EC, FADK-1, FAK-1, FAK1, Focal Adhesion Kinase 1, PTK2, Protein Tyrosine Kinase Cytoplasmic, Protein-Tyrosine Kinase 2, pp125FAK
Presentation Aff - Purified
Reactivity Hu, Rt
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Swiss Prot Num:
The antiserum was produced against synthesized non-phosphopeptide derived from human FAK around the phosphorylation site of tyrosine 397 (D-D-YP-A-E).
Add. information Research Areas: Cancer
Application immunohistochemistry, Western Blot, This antibody is useful for: Western Blot 1:500-1:1000 immunohistochemistry 1:50-1:100, Western Blot 1:500-1:1000, immunohistochemistry 1:50-1:100,
Background Focal adhesion kinase (FAK) is a non receptor protein tyrosine kinase discovered as a substrate for Src and as a key element of integrin signaling. FAK plays a central role in cell spreading, differentiation, migration, cell death and acceleration of the G1 to S phase transition of the cell cycle. FAK regulation includes phosphorylation at multiple tyrosine and serine residues. Phosphorylation of tyrosine generally is associated with positive regulation and growth promotion, however, dephosphorylation at these sites occurs as cells enter mitosis (M-Phase of the cell cycle). In contrast, serine phosphorylation either remains high or is increased as cells enter mitosis and may play a role in focal adhesion disassembly. FAK and its phosphorylation states have been implicated in cancer metastasis and tumor cell survival and adhesion-independent growth. Additionally, recent evidence indicates that elevation of FAK activity in human carcinoma cells is associated with increased invasive potential. A central role in tumor formation and progression suggests that FAK is an attractive target for therapeutic intervention.
Concentration 1 mg/ml
General Readings von Sengbusch A, et al. (2005) Am J Pathol ; 166(2): 585-596
Fornaro M, et al. (2000) Mol Biol Cell ; 11(7): 2235-2249
Zhang X, et al. (1999) Proc Natl Acad Sci U S A; 96(16): 9021-9026.
Storage Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Immunogen affinity purified
Buffer System:
0.02% Sodium Azide
Immunogen affinity purified
Aff - Purified
FAK (specific to a.a. 397) detects endogenous levels of total FAK protein.
Human, Rat
Gene ID 142986
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