NBP1-30055 Fibrillarin (38F3) antibody

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Mouse anti Human, Rat Fibrillarin (38F3) 38F3


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  • NBP1-30055

Product Description for Fibrillarin (38F3)

Mouse anti Human, Rat Fibrillarin (38F3) 38F3.
Presentation: Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot.

Properties for Fibrillarin (38F3)

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms anti-FBL antibody, anti-FIB antibody, anti-FLRN antibody, anti-Fibrillarin antibody, anti-RNU3IP1 antibody
Presentation Purified
Reactivity Hu, Rt
Applications ICC/IF, WB
Clonality Monoclonal
Clone 38F3
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Yeast nuclear preparations.
Isotype control AM03095PU-N, SM10P (for use in human samples), SM20P (for use in rat samples)
Add. information Research Areas: Stem Cell Markers, Cellular Markers
Application immunofluorescence, Western Blot, This antibody useful in Western Blot and Immunofluorescence., immunofluorescence 1:500, Western Blot 1:1,000
Background Nop1p / Fibrillarin was originally identified as a nucleolar protein of bakers yeast, Saccharomyces cerevisiae (accession P15646). The Nop1p protein is essential for yeast viability and is localized in the nucleoli. The human homologue of Nop1p is fibrillarin (accession P22087) a component of the nucleolar small nuclear ribonucleoprotein (snRNP) particle. The human fibrillarin gene is located on chromosome 19 (19q13.1). Fibrillarin proteins have been cloned and sequenced from several other species (Mouse, accession P35550, Xenopus accession P22232, C. elegans accession Q22053, and S. pombe accession P35551). The N terminal 80 amino acids contain multiple copies based on the peptide RGG, and the remaining 240 amino acids consist of the fibrillarin domain. A fibrillarin homologue has also been identified in the genome of the archean Methanococcus (accession NC_000909). This protein lacks the RGG rich N-terminal extension but is clearly homologous to the other sequences throughout all of the fibrillarin domain. The structure of this molecule has been determined and shown to consist of 2 extended beta-sheets flanked by 4 alpha-helixes. Patients with the autoimmune disease scleroderma often have strong circulating autoantibodies to a 34kDa protein which was subsequently found to be fibrillarin. Fibrillarin is an excellent marker for the nucleolus.
Storage Store at -20C. Avoid freeze-thaw cycles.
IgG purified
Buffer System:
10mM Sodium Azide
IgG purified
Specific for the ~34kDa Fibrillarin /Nop1p protein.
C. elegans, Drosophila, Human, Plant, Rat, Yeast

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