BM2330 Fibrin/Fibrinogen antibody

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Mouse anti Canine, Human Fibrin/Fibrinogen MFB-HB


Product Description for Fibrin/Fibrinogen

Mouse anti Canine, Human Fibrin/Fibrinogen MFB-HB.
Presentation: Purified
Product is tested for Frozen Sections, Enzyme Immunoassay, Immunocytochemistry/Immunofluorescence.

Properties for Fibrin/Fibrinogen

Product Category Primary Antibodies
Quantity 1 ml
Synonyms FGA, FGB, FGG, Fibrinogen alpha chain, Fibrinogen beta chain, Fibrinogen gamma chain, Fibrinopeptide A, Fibrinopeptide B
Presentation Purified
Reactivity Can, Hu
Applications C, E, ICC/IF
Clonality Monoclonal
Clone MFB-HB
Host Mouse
Isotype IgM
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Isotype control SM13P
Application Staining sections by Immunohistochemistry or Immunofluorescence: It reveals early and aged fibrinous depositions.
ELISA: Determination of fibrin related products in biological fluids, 1:1000 starting dilution.
It can easily be conjugated to peroxidase, FITC, and TRITC.
Immunohistology on Acetone or Ethanol fixed Cryostat Sections: 1/30-1/50 dilution preferably in PBS.
Background Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases.
The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel A. et al, and Rapold H.J. et al). All these facts make fibrinogen an important parameter in the diagnosis of cardiovascular diseases.
Concentration 0.5 mg/ml (prior to lyophilization)
Storage Store lyophilized product at -20°C.
Upon reconstitution, store product at 2-8°C for one month, then aliquot and store at -20°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
PEG6000 Precipitation and DEAE-Cellulose Chromatography, Gradient Elution.
Lyophilized purified Ig fraction with 0.09% Sodium Azide as preservative.
Restore with 1 ml distilled water.
Reacts specifically with Fibrin.
It binds with moderate affinity to human Fibrinogen, but does not react with other human plasma proteins.
Human and Canine.

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