AP01776PU-N FOXO1/3/4-pan pThr24/32 antibody

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Rabbit anti Human, Mouse, Rat FOXO1/3/4-pan

Product Description for FOXO1/3/4-pan

Rabbit anti Human, Mouse, Rat FOXO1/3/4-pan.
Properties: pThr24/32
Presentation: Aff - Purified
Product is tested for Paraffin Sections.

Properties for FOXO1/3/4-pan

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms FOXO1A, FOXO3A, FOXO4A, Forkhead Box Protein O1A, Forkhead in Rhabdomyosarcoma
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications P
Clonality Polyclonal
Host Rabbit
Molecular weight ~ 70 to 82 kDa
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Property pThr24/32
Application Immunohistochemistry on paraffin sections: 1/50-1/200.
Background FOXO1 + FOX3 + FOX4 belong to the forkhead family of transcription factors. FOXO1 (FKHR or ForkHead in Rhabdomyosarcoma) is a 70 kDa protein. Recent studies have shown that this protein can act as either a coactivator or a corepressor of nuclear receptor activity. This action is mediated through the LXXLL motif found in the C terminus of the FOXO1A protein. The specific function of the gene has not yet been determined. FOX3 probably functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of the FOXO3 gene with the MLL gene is associated with secondary acute leukemia. FOX4 is a forkhead transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO4 down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle.
Concentration 1.0 mg/ml
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: One year from despatch.
Affinity Chromatography using epitope-specific immunogen.
Buffer System:
Phosphate buffered saline (PBS), pH~7.2 containing 0.05% Sodium Azide as preservative.
Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
Aff - Purified
Species Reactivity
Species reactivity (expected):
Mouse and Rat.
Species reactivity (tested):
This antibody detects endogenous levels of of FOXO1/3/4-pan pThr24/32 protein.
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