AP08647SU-N Fractin (C-term) antibody

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0.1 ml / €340.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Rabbit anti Human, Rat Fractin

Product Description for Fractin

Rabbit anti Human, Rat Fractin.
Properties: (C-term)
Presentation: Serum
Product is tested for Frozen Sections, Western blot / Immunoblot.

Properties for Fractin

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms Fragment of Actin
Presentation Serum
Reactivity Hu, Rt
Applications C, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Synthetic peptide taken from the C terminus of the 32-kDa Actin fragment.
Property C-term
Application Western Blot: 1/1000.
Immunohistochemistry: 1/100.
Background Fractin (fragment of Actin) is a Caspase-specific cleavage product of actin and serves as a novel marker of apoptosis-related events. It has recently been reported that Fractin may have a functional role in apoptotic signaling in oligodendrocytes (Schulz, R., et al., Glia, 2009, in press).
General Readings
  1. Yang F, Sun X, Beech W, Teter B, Wu S, Sigel J, et al. Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease. Am J Pathol. 1998 Feb;152(2):379-89. PubMed PMID: 9466564. (Free PMC Article available)
  2. Rossiter JP, Anderson LL, Yang F, Cole GM. Caspase-cleaved actin (fractin) immunolabelling of Hirano bodies. Neuropathol Appl Neurobiol. 2000 Aug;26(4):342-6. PubMed PMID: 10931367.
  3. Adamec E, Yang F, Cole GM, Nixon RA. Multiple-label immunocytochemistry for the evaluation of nature of cell death in experimental models of neurodegeneration. Brain Res Brain Res Protoc. 2001 Jul;7(3):193-202. PubMed PMID: 11431120.
  4. Chen TA, Yang F, Cole GM, Chan SO. Inhibition of caspase-3-like activity reduces glutamate induced cell death in adult rat retina. Brain Res. 2001 Jun 15;904(1):177-88. PubMed PMID: 11516428.
  5. Rossiter JP, Anderson LL, Yang F, Cole GM. Caspase-3 activation and caspase-like proteolytic activity in human perinatal hypoxic-ischemic brain injury. Acta Neuropathol. 2002 Jan;103(1):66-73. PubMed PMID: 11841033.
Storage Store the antibody undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
State:
Liquid Neat Serum without preservatives.
Serum
Species Reactivity
Species reactivity (tested):
Human and Rat.
Specificity
Specificity:
Specific for the ~ 32 kDa Fractin protein in Western blots with no reactivity to intact actin. There is often a ladder of smaller bands in cells or culture or in vivo preparations due to further degradation by other proteases.
The antibody has been shown to detect the processes and cell bodies of degenerating neurons and plaque-associated microglia in Alzheimer's disease. (Ref.1)

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