discontinued

NB100-66171 GABA A Receptor antibody

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0.05 ml / €550.00

Quick Overview

Rabbit anti Rat GABA A Receptor

NB100-66171

Product Description for GABA A Receptor

Rabbit anti Rat GABA A Receptor.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for GABA A Receptor

Product Category Primary Antibodies
Quantity 0.05 ml
Presentation Aff - Purified
Reactivity Rt
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
Synthetic peptide corresponding to a region within the alpha 1 subunit of rat GABAA receptor.
Add. information Research Areas: Neuroscience
Application Western Blot, Western Blot detects a band of approximately 51kDa in rat cortex cell lysates., Western Blot 1:1000
Background Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter. GABA acts at inhibitory synapses in the brain and spinal cord. Inhibition is provoked by GABA binding resulting in hyperpolarization of the synaptic transmembrane potential of the affected neuron. GABA binding causes ion channels to open allowing either the flow of chloride or potassium ions into or out of the cell.
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Format
Purification:
Whole antisera
Buffer System:
0.09% Sodium Azide
Purity:
Whole antisera
State:
Aff - Purified
Specificity
Specificity:
NB100-66171 is specific for the alpha 1 subunit of rat gamma-aminobutyric acid A (GABAA) receptor. GABAA receptors are GABA gated chloride channels, which are important mediators of neuronal inhibition in the mammalian central nervous system. Activation of the GABAA site results in increased intracellular chloride concentration and hyperpolarization of the cell. GABAA receptors are pentameric structures assembled from a family of distinct subunits. At least fourteen distinct subunits have been identified, which show distinct patterns of temporal and spatial expression. GABAA receptors may be modulated by several drug types including benzodiazepines and barbiturates, and by phosphorylation by protein kinase C (PKC) and protein kinase A (PKA).
Species:
Bovine, Canine, Chicken, Human, Mouse, Primate, Rat

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