GTX30220 GABA-B receptor 2 subunit phosphorylated antibody

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0.1 ml / €480.00

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Rabbit anti Human, Mouse, Rat GABA-B receptor 2 subunit phosphorylated


Product Description for GABA-B receptor 2 subunit phosphorylated

Rabbit anti Human, Mouse, Rat GABA-B receptor 2 subunit phosphorylated.
Presentation: Aff - Purified
Product is tested for Frozen Sections, Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot.

Properties for GABA-B receptor 2 subunit phosphorylated

Product Category Primary Antibodies
Quantity 0.1 ml
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications C, ICC/IF, WB
Clonality Polyclonal
Host Rabbit
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Synthetic phosphopeptide - amino acid residues surrounding the phosphoSer892 of rat GABA BR2 subunit.
Application IF, IHC, WB
Background Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors the GABAA and the GABAB subtype of receptors. GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. Moss and colleagues (Couve, et al., 2002) recently demonstrated that the functional coupling of GABAB R1/GABAB R2 receptors to inwardly rectifying K+ channels rapidly desensitizes. This effect is alleviated after direct phosphorylation of a single serine residue (Ser892) in the cytoplasmic tail of GABAB R2 by cyclic AMP (cAMP)-dependent protein kinase (PKA). In addition to it postsynaptic effects GABAB receptors localized to the presynaptic region have been reported to restrict the availability of synaptic vesicles for release (Sakaba and Neher, 2003).
Concentration 0.1 mg/ml
Storage Keep as concentrated solution. Aliquot and store at -20
Affinity purified
Buffer System:
10 mM HEPES, pH7.5, containing 150 mM NaCl, 50% glycerol and 100ug/ml BSA
Affinity purified
Aff - Purified
Human, Rat and Mouse - Not yet tested in other species

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