AP30357PU-N GAS antibody

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Rabbit anti Human, Mouse GAS

Product Description for GAS

Rabbit anti Human, Mouse GAS.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.

Properties for GAS

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms Glutamate-rich coactivator interacting with SRC1, PA1, PTIP-associated 1 protein
Presentation Aff - Purified
Reactivity Hu, Ms
Applications E, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Swiss Prot Num:
GAS antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human GAS. (AP30357CP-N)
Add. information Blocking peptide available: blocking peptide (AP30357CP-N)
Application ELISA.
Western Blot: 1 - 2 μg/ml.
Background Steroid receptor co-activators (SRCs) were initially described as nuclear receptor transcription co-activators, but they have recently been determined to co-regulate transcription initiated by other transcription factors. GAS is a recently identified glutamate-rich protein that interacts with SRC1, but not GRIP1 or AIB1, the other two members of the SRC family. GAS can also interact with the alpha subunit of the estrogen receptor (ERa), but not other receptors such as the retinoic acid receptor a, suggesting the interaction between GAS and ERa is relatively specific. Depletion of GAS by RNA interference in MCF7 cells led to a decrease in the mRNA and protein levels of ER target genes such as pS2, c-Myc and cyclin D1, indicating the role of GAS in the regulation of ER target genes. GAS has also been found to associate with an SET1-like methyltransferase complex specific for H3K4 methylation, suggesting that GAS has multiple roles in transcriptional regulation.
Concentration 1.0 mg/ml
General Readings
  1. Xu J, Wu RC, O'Malley BW. Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family. Nat Rev Cancer. 2009 Sep;9(9):615-30. doi: 10.1038/nrc2695. PubMed PMID: 19701241. (Free PMC Article available, 3 images available)
  2. Liang J, Zhang H, Zhang Y, Zhang Y, Shang Y. GAS, a new glutamate-rich protein, interacts differentially with SRCs and is involved in oestrogen receptor function. EMBO Rep. 2009 Jan;10(1):51-7. doi: 10.1038/embor.2008.223. Epub 2008 Nov 28. PubMed PMID: 19039327. (Free PMC Article available, 5 images available)
  3. Cho YW, Hong T, Hong S, Guo H, Yu H, Kim D, et al. PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J Biol Chem. 2007 Jul 13;282(28):20395-406. Epub 2007 May 11. PubMed PMID: 17500065. (Free PMC Article available, 7 images available)
Storage Store the antibody (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Affinity chromatography purified via peptide column
Buffer System:
PBS containing 0.02% sodium azide.
Liquid purified Ig fraction
Aff - Purified
Human, mouse
Gene ID 2716513

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