discontinued

AM32097PU-N Gastrin antibody

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Mouse anti Human Gastrin G52C7.1

AM32097PU-N

Product Description for Gastrin

Mouse anti Human Gastrin G52C7.1.
Presentation: Ig Fraction
Product is tested for Enzyme Immunoassay, Paraffin Sections.

Properties for Gastrin

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms GAS, GAST
Presentation Ig Fraction
Reactivity Hu
Applications E, P
Clonality Monoclonal
Clone G52C7.1
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P01350
Immunogen:
Synthetic (modified) Gastrin-17 coupled to thyroglobulin.
Hybridoma produced by fusion between myeloma cells and Balb/c spleen cells.
GeneID:
2520
Application Enzyme Immunoassays. 
Immunohistochemistry on Paraffin Sections.
Background Amidated Gastrin-17 is a biologically and physiologically important molecule among the family of the gastrin peptides. Amidated gastrin-17 is the most powerful gastrin peptide in the feedback control mechanism of the acid secretion and output from the parietal cells in the gastric corpus. This peptide is solely synthetized and secreted into the circulation by the so called G cells (“gastrin cells”) in the gastric antrum. A positive immunohistochemical reaction for gastrin-17 is a sign of a highly differentiated gastrin-secreting cell and normal antral mucosa. In atrophic gastritis, the normal antral (pyloric) glands and gastrin-17 synthetizing cells disappear. Metaplastic pyloric glands (pseudopyloric metaplasia) do not contain immunopositive gastrin-17 cells.
Concentration 0.1 mg/ml
General Readings
  1. Varis K. Surveillance of pernicious anemia. In Precancerous Lesions of the Gastrointestinal Tract. Scherlock P, Morson PC, Barbara L, Veronesi U (eds), Raven Press, New York, 189-194, 1983.
  2. Sipponen P, Kekki M, Haapakoski J, Ihamäki T, Siurala M. Gastric cancer risk in chronic atrophic gastritis: statistical calculations of cross-sectional data. Int J Cancer. 1985 Feb 15;35(2):173-7. PubMed PMID: 3871738.
  3. Hallissey MT, Dunn JA, Fielding JW. Evaluation of pepsinogen A and gastrin-17 as markers of gastric cancer and high-risk pathologic conditions. Scand J Gastroenterol. 1994 Dec;29(12):1129-34. PubMed PMID: 7886402.
  4. Sipponen P, Valle J, Varis K, Kekki M, Ihamäki T, Siurala M. Fasting levels of serum gastrin in different functional and morphologic states of the antrofundal mucosa. An analysis of 860 subjects. Scand J Gastroenterol. 1990 May;25(5):513-9. PubMed PMID: 2359980.
Storage

Store the antibody undiluted at 2-8°C.
Shelf life: one year from despatch.

Format
Buffer System:
PBS
Preservatives:
0.09 % Sodium Azide
Stabilizers:
1.0% BSA
State:
Liquid Ig fraction
Ig Fraction
Species Reactivity
Species reactivity (tested):
Human.
Specificity
Specificity:
The antibody Clone G52C7.1 is specific to Gastrin-17 with no crossreactivity to Gastrin-34 or Cholecystokinin.
Gene ID 2520

Accessory Products

Proteins and/or Positive Controls

Proteins for Gastrin (6 products)

Catalog No. Species Pres. Purity   Source  

Gastrin

Gastrin Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €748.00
  OriGene Technologies, Inc.

Gastrin (Gastrin-17, G17)

Gastrin Human Purified >95% pure (HPLC) Synthetic
  OriGene Technologies GmbH

Gastrin (Gastrin-17, G17)

Gastrin Human Purified Solid phase synthesis - HPLC: 98.7%
  OriGene Technologies GmbH

Gastrin (Big-Gastrin, G34)

Gastrin Human Purified Solid phase synthesis - HPLC: 98.9%
  OriGene Technologies GmbH

Gastrin (full length)

Gastrin Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
  Abnova Taiwan Corp.

Gastrin (full length)

Gastrin Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
  Abnova Taiwan Corp.

Positive controls for Gastrin (1 products)

Catalog No. Species Pres. Purity   Source  

Gastrin peptide Lysate

Western Blot: Gastrin peptide Lysate [NBL1-10978] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for GAST
  Novus Biologicals Inc.
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