AP09728PU-N Gestrinone antibody

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0.1 ml / €600.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Sheep anti Gestrinone


Product Description for Gestrinone

Sheep anti Gestrinone.
Presentation: Ig Fraction
Product is tested for Enzyme Immunoassay.

Properties for Gestrinone

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms Dimetriose, Dimetrose, Ethylnorgestrienone, Gestrigone, Gestrinonum, Nemestran, Tridomose
Presentation Ig Fraction
Applications E
Clonality Polyclonal
Host Sheep
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Application ELISA: 0.039 µg/ml.
Background Endometriosis is common disease characterized by the presence of endometrial tissue outside the uterus which affects approximately 10% of premenopausal women. Gestrinone is a synthetic steroid used occasionally to treat endometriosis.(1) It acts centrally on the hypothalamic-pituitary system to suppress release of lutenizing hormone (LH) and follicle-stimulating hormone (FSH), thus reducing estrogen synthesis.(1) It also binds to androgen (AR), progesterone (PR), and estrogen (ER) receptors in the human endometrial tissue but not to steroid hormone binding globulin or corticord-binding globulin.(2) Gestrinone binds to AR and PR with EC50 values of approximately 20 and 30 nM, respectively.(3) These values reflect approximately 5-6 fold lower affinity than testosterone and progesterone, the natural AR and PR ligands, for these receptors.(3)
Concentration 10.20 mg/ml (U.V.abs @ 280nm)
General Readings
  1. Moghissi, K.S. Medical treatment of endometriosis. Clin Obstet Gynecol 45(3) 620-633 (1999).
  2. Tamaya T, Fujimoto J, Watanabe Y, Arahori K, Okada H. Gestrinone (R2323) binding to steroid receptors in human uterine endometrial cytosol. Acta Obstet Gynecol Scand. 1986;65(5):439-41. PubMed PMID: 3490730.
  3. Death AK, McGrath KC, Kazlauskas R, Handelsman DJ. Tetrahydrogestrinone is a potent androgen and progestin. J Clin Endocrinol Metab. 2004 May;89(5):2498-500. PubMed PMID: 15126583.
Storage Store the antibody (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Buffer System:
20mM Phosphate, 150mM Sodium Chloride, pH 7.2 containing 0.09% Sodium Azide as preservative.
Liquid Ig fraction prepared by Caprylic Acid and Ammonium Sulphate precipitation procedures.
Ig Fraction
This antibody recognizes Gestrinone.

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