NBP1-05104 Gliadin-related peptide Lys57-Glu65 antibody

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Mouse anti Gliadin-related peptide Lys57-Glu65


Product Description for Gliadin-related peptide Lys57-Glu65

Mouse anti Gliadin-related peptide Lys57-Glu65.
Presentation: Purified
Product is tested for Enzyme Immunoassay.

Properties for Gliadin-related peptide Lys57-Glu65

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Purified
Applications E
Clonality Polyclonal
Host Mouse
Isotype IgG2a
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Gliadin-related peptide Lys57-Glu65-[alpha-gliadin (58-73)] (KLQPFPQPELPYPQPQ) coupled to immunogenic carrier protein.
Application ELISA, ELISA, ELISA 1:20000,
Background Celiac disease is associated with a CD4+ T-cell response to epitopes of gliadin presented by HLA-DQ2 or -DQ8 class II MHC molecules. These epitopes are present in a 33-mer peptide of wheat alpha-gliadin, residues 56-88, which is resistant to digestion and forms a substrate for tissue transglutaminase (TG2), generating the glutamic acid residues essential for binding to HLA-DQ2. The immunogen corresponds to a deamidated form of a region that includes the T-cell epitopes, including the immunodominant PQPQLPY region and two PXPQP motifs associated with binding to IgA from patients with celiac disease. Complete homology exists between residues 63-73, 70-80 and 77-87 of wheat alpha gliadin.
Concentration 1 mg/ml
General Readings
  1. Skovbjerg H, Koch C, Anthonsen D, Sjöström H. Deamidation and cross-linking of gliadin peptides by transglutaminases and the relation to celiac disease. Biochim Biophys Acta. 2004 Nov 5;1690(3):220-30. PubMed PMID: 15511629.
  2. Mowat AM. Coeliac disease--a meeting point for genetics, immunology, and protein chemistry. Lancet. 2003 Apr 12;361(9365):1290-2. PubMed PMID: 12699968.
Storage Store at 4C. Do not freeze.
protein A purified
Buffer System:
15mM Sodium Azide
protein A purified
The epitope is located in the Lys57-Glu65-[alpha-gliadin (58-73)] (KLQPFPQPELPYPQPQ) peptide., HYB 314-02 cross-reacts with the non-deamidated peptide KLQPFPQPQLPYPQPQ

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