NBP1-19394 Glutamate receptor 4 antibody

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0.1 mg / €420.00
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Rabbit anti Human, Mouse, Rat Glutamate receptor 4

NBP1-19394

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  • NBP1-19394

Product Description for Glutamate receptor 4

Rabbit anti Human, Mouse, Rat Glutamate receptor 4.
Presentation: Aff - Purified
Product is tested for Paraffin Sections, Western blot / Immunoblot.

Properties for Glutamate receptor 4

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms anti-GRM4 antibody, anti-Gprc1d antibody, anti-mGlu4 antibody, anti-mGluR4 antibody
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications P, WB
Clonality Polyclonal
Host Rabbit
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q1WWK6
GeneID:
2893
Application immunohistochemistry, Western Blot, This antibody is useful for Western Blot and Immunohistochemistry. Western blot analysis of GluR4 (K858) antibody in extracts from NIH/3T3 cells. Immunohistochemistry analyzes of GluR4 (K858) antibody in paraffin-embedded human brain tissue., Western Blot 1:500-1:1000, immunohistochemistry 1:50-1:200,
Background G protein-coupled inwardly rectifying potassium channels (KIR3.1 through KIR3.4) are coupled to numerous neurotransmitter receptors in the brain and are abundantly expressed in the olfactory bulb, hippocampus, neocortex, dentate gyrus, cerebellar cortex and thalamus regions of the brain. Also known as GIRK, KIR3 potassium channels localize to the soma and dendrites as well as axons of neurons. Liberated Gbgamma subunits from G protein heterotrimers bind to and regulate KIR3 channel activity. Gb3- and Gb4-containing Gbgamma dimers bind directly to cytoplasmic domains of KIR3 proteins and increase the K+ current while Gb5-containing Gbgamma dimers inhibit KIR3 K+ current. KIR3 activity is also inhibited by tyrosine phosphorylation. Brain-derived neurotrophic factor activates receptor tyrosine kinase B, which then phosphorylates KIR3 tyrosine residues, effectively inactivating the KIR3 channels.
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Format
Purification:
Affinity purified
Buffer System:
No Preservative
Purity:
Affinity purified
State:
Aff - Purified
Specificity
Specificity:
GluR4 (K858) detects endogenous levels of GluR4 protein.
Species:
Human, Mouse, Rat
Gene ID 2893

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