discontinued

AP05370SU-N Glutathione antibody

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0.1 ml / €690.00

Quick Overview

Rat anti Glutathione

AP05370SU-N

Product Description for Glutathione

Rat anti Glutathione.
Presentation: Serum
Product is tested for Enzyme Immunoassay.

Properties for Glutathione

Product Category Primary Antibodies
Quantity 0.1 ml
Presentation Serum
Applications E
Clonality Polyclonal
Host Rat
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Glutathione-gluteraldehyde-BSA conjugate.
Application ELISA: 1/5000 - 1/10,000.
Background Glutathione is a small peptide composed of three amino acids: cysteine, glutamic acid, and glycine and is present in tissues in concentrations as high as one millimolar. It contains an unusual peptide linkage between the amine group of cysteine and the carboxyl group of the glutamate side chain. Glutathione is involved in detoxification, it binds to toxins, such as heavy metals, solvents, and pesticides, and transforms them into a form that can be excreted in urine or bile. It is also an important antioxidant, helping to maintain the -SH groups of proteins in their reduced form.

Chronic functional glutathione deficiency is associated with glucose 6-phosphate dehydrogenase deficiency, immune disorders, an increased incidence of malignancies, and in the case of HIV disease, probably accelerated pathogenesis of the disease. Acute manifestations of functional glutathione deficiency can be seen in those who have taken an overdosage of acetaminophen (paracetamol). This results in depletion of glutathione in the hepatocytes, leading to liver failure and death.
Storage Prior to reconstitution store at 2-8°C.
Following reconstitution store the antibody at -20°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
State:
Lyophilised serum
Serum
Reconstitution:
50 µl distilled water + 50 µl glycerol
Specificity
Specificity:
This antibody recognises glutathione, a tripeptide antioxidant found within cells mainly in its reduced form. This antibody has been adsorbed against BSA but only recognises conjugated glutathione, not free glutathione.

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