discontinued

AP32365SU-N Glutathione antibody

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0.1 ml / €460.00

Quick Overview

Rat anti Eukaryote Glutathione

AP32365SU-N

Product Description for Glutathione

Rat anti Eukaryote Glutathione.
Presentation: Serum
Product is tested for Frozen Sections.

Properties for Glutathione

Product Category Primary Antibodies
Quantity 0.1 ml
Presentation Serum
Reactivity Eu
Applications C
Clonality Polyclonal
Host Rat
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Glutathione-Glutaraldehyde-BSA
Application Immunohistochemistry: 1/1,000-1/2,500 by PAP.
Background Glutathione is a small peptide composed of three amino acids: cysteine, glutamic acid, and glycine and is present in tissues in concentrations as high as one millimolar. It contains an unusual peptide linkage between the amine group of cysteine and the carboxyl group of the glutamate side chain. Glutathione is involved in detoxification, it binds to toxins, such as heavy metals, solvents, and pesticides, and transforms them into a form that can be excreted in urine or bile. It is also an important antioxidant, helping to maintain the -SH groups of proteins in their reduced form.

Chronic functional glutathione deficiency is associated with glucose 6-phosphate dehydrogenase deficiency, immune disorders, an increased incidence of malignancies, and in the case of HIV disease, probably accelerated pathogenesis of the disease. Acute manifestations of functional glutathione deficiency can be seen in those who have taken an overdosage of acetaminophen (paracetamol). This results in depletion of glutathione in the hepatocytes, leading to liver failure and death.
General Readings
  1. Amara, A. et al, Brain Research. (1994) 659:237-242.
Storage Store (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch. 
Note: During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For antibodies with volumes of 200 μl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Format
Preservatives:
0.09% Sodium Azide
State:
Liquid Serum
Serum
Specificity
Specificity:
This antibody recognises Glutathione, a tripeptide antioxidant found within cells mainly in its reduced form.
The cross-reactivities were determined using either ELISA or RIA techniques, at concentration/unconjugated or conjugated amino acid concentration at half displacement.
Compound : Cross-reactivity Ratio
Glutathione-G-BSA: 1
Cysteine-G-BSA: 1/> 10,000.
Glutamate-G-BSA: 1/> 10,000.
Glycine-G-BSA: 1/> 10,000. 

G = Glutaraldehyde, BSA = Bovine Serum Albumin

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