discontinued

GTX17059 Glycogen Synthase Kinase 3 alpha/beta (GSK3a/b) antibody

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50 µg / €90.00

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Mouse anti Human, Mouse, Rat Glycogen Synthase Kinase 3 alpha/beta (GSK3a/b) 1H8

GTX17059

Product Description for Glycogen Synthase Kinase 3 alpha/beta (GSK3a/b)

Mouse anti Human, Mouse, Rat Glycogen Synthase Kinase 3 alpha/beta (GSK3a/b) 1H8.
Presentation: Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.

Properties for Glycogen Synthase Kinase 3 alpha/beta (GSK3a/b)

Product Category Primary Antibodies
Quantity 50 µg
Synonyms EC 2.7.11.26, EC=2.7.11.26, GSK-3 alpha, GSK-3 beta, GSK3A, GSK3B, Glycogen synthase kinase-3 alpha, Glycogen synthase kinase-3 beta
Presentation Purified
Reactivity Hu, Ms, Rt
Applications E, WB
Clonality Monoclonal
Clone 1H8
Host Mouse
Isotype IgG2a
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Immunogen
Immunogen:
Antigen is recombinant Xenopus laevis GSK3 beta protein.
Isotype control AM03096PU-N
Application ELISA, WB
Background Glycogen synthase kinase 3 (GSK3) is a proline directed serine threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase, a key enzyme in glycogen metabolism. Since then, it has been shown to be involved in the regulation of a diverse array of cellular functions, including protein synthesis, cell proliferation, cell differentiation, microtubule assembly/disassembly, and apoptosis. GSK3s substrate specificity is unique in that phosphorylation of substrate only occurs if a phosphoserine or phosphotyrosine is present four residues C terminal to the site of GSK phosphorylation.There exists two isoforms of GSK3, alpha and beta, and they show a high degree of amino acid homology (Stambolic and Woodgett, 1994 [PubMed 7980435]). The two isoforms of GSK3 are strictly regulated via phosphorylation. Phosphorylation of GSK3 beta on Ser9 (Ser21 in GSK3 alpha) by protein kinase B (PKB) causes its inactivation is the primary mechanism responsible for growth factor inhibition of this kinase. Activation of GSK3 beta is dependent upon the phosphorylation of Tyr216 (Tyr279 in GSK3 alpha). Upon activation, it has been shown to phosphorylate a number of different cellular proteins, including p53, c-Myc, c-Jun, heat shock factor 1 (HSF1), and cyclin D1. GSK3 beta also has been shown to phosphorylate aberrant sites on the microtubule associated protein tau, which is critical for the progression of Alzheimers disease. GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation (Plyte et al., 1992 [PubMed 1333807]).
Concentration 1 mg/ml
Storage Keep as concentrated solution. Store at 4
Format
Purification:
Protein A purified
Buffer System:
Preservative: 0.01% Sodium Azide. Constituents: PBS.
Purity:
Protein A purified
State:
Purified
Specificity
Specificity:
Cross-reacts with Human, Mouse, Rat and Amphibians. Not yet tested in other species.

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